Results 61 to 70 of about 414 (210)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Maintaining the working state of firefighters by utilizing self-concept clarity as a resource

BMC Public Health
The working state of firefighters is important for their own safety as well as that of the general public. The purpose of this study is to investigate the correlations between self-concept clarity, resilience, work engagement, and job burnout among ...
Peng Wu, Tingting Liu, Qingqian Li, Xiaoting Yu, Zhiyun Liu, Siyu Tian   +5 more
doaj   +1 more source

The effect of future self-continuity on intertemporal decision making: a mediated moderating model

Frontiers in Psychology
Intertemporal decision making refers to the behavior of making decisions after weighing the costs and benefits of two or more outcomes at different time points.
Ying Yang, Ying Yang, Liangxiangwan Zhang, Liangxiangwan Zhang, Weiguo Qu, Weiguo Qu, Wei Fan, Wei Fan, Wei Fan   +8 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Self‐concept clarity and responsiveness to false feedback

Social Influence, 2007
We examined the extent to which people high and low in helpful and honest self‐concept clarity use labeling to guide decisions about their behavior. High helpful self‐concept clarity participants in Experiment 1 who received feedback indicating they were helpful were more likely to assist a confederate who dropped some pamphlets than were those not ...
Rosanna E. Guadagno, Jerry M. Burger
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The role of enmeshment and undeveloped self, subjugation and self-sacrifice in childhood trauma and attachment related problems: The relationship with self-concept clarity

Acta Psychologica
Background: Schema Theory posits that childhood trauma and unmet emotional needs lead to the formation of Early Maladaptive Schemas (EMS). However, the connection between EMS and self-concept clarity remains unexplored. Objective: This study examines how
Cristina M.C. Baroncelli, Paul Lodder, Marije van der Lee, Nathan Bachrach   +3 more
doaj   +1 more source

Self-Concept Clarity and Loneliness among College Students: The Chain-Mediating Effect of Fear of Negative Evaluation and Self-Disclosure

Behavioral Sciences
Self-concept clarity is considered a crucial indicator of mental health. Although several studies have examined the correlation between self-concept clarity and loneliness, few studies have investigated the underlying mechanism. Based on the evolutionary
Tingting Pang, Haiying Wang, Xinran Zhang, Xianbing Zhang   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source