Results 81 to 90 of about 414 (210)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Effects of Value Conflicts on Stress in Chinese College Students: A Moderated Mediation Model

Behavioral Sciences
Limited research has explored the connection between stress and value conflicts, particularly the influence of self-construal and self-concept clarity. This study surveyed a sample of 752 Chinese college students using the Depression–Anxiety-Stress Scale,
Xiaoxiao Ren, Hao Xu, Tong Yue, Tong Wang   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Childhood Unpredictability and Smartphone Addiction in Chinese Adolescents: Mediating Role of Self-Concept Clarity and Self-Control and Moderating Role of Psychological Resilience

Behavioral Sciences
As a distal factor influencing adolescents’ psychological development and behavioral adaptation, the question of whether and how childhood unpredictability is associated with smartphone addiction remains unclear.
Qingqing Li, Mingyang Zhang, Hailan Wang, Wenjing Liu, Yanjing Wang, Zhuoran Li, Zhenrong Fu   +6 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Identidad vocacional, claridad del autoconcepto y autoestima en adolescentes peruanos [PDF]

Psychology, Society & Education, 2015
Vocational choice represents a fundamental task in late adolescence and, as such, it is directly involved with the multiple aspects of the self. The aim of this study was to describe the relationship between the variables of Self-Esteem and Self-Concept ...
Joaquín Castro Valdez
doaj  

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Personal identity of modern adolescents: results of an all-Russian study

Психологическая наука и образование
Context and relevance. The theoretical significance of the work is related to the need to correlate the cultural-historical approach to understanding adolescence, as well as theories of identity and modern ideas about the dynamics of Self ...
I.V. Shapovalenko, Y.A. Kochetova, G.V. Semya, I.A. Merkul, A.S. Radchikov   +4 more
doaj   +1 more source