Results 41 to 50 of about 484,615 (266)

A Comparison of Direct and Indirect Flexibilities on the Self-Consumption of an Office Building: The Case of Predis-MHI, a Smart Office Building

Frontiers in Energy Research, 2022
The purpose of this paper is to provide a method for assessing the impact of direct and indirect flexibilities on the self-consumption of office buildings. The goal is to assess how both the human actors and technical interventions can affect or mitigate
Nana Kofi Twum-Duah, Nana Kofi Twum-Duah, Manar Amayri, Stéphane Ploix, Frédéric Wurtz   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Self-Consumption and Frequency Reserve Provision With Energy Communities

IEEE Access, 2023
The increased concern for greener and more sustainable energy has prompted the wide development of local initiatives such as energy communities (EC) in which several users can be gathered to reach more efficient energy usage. This paper presents an optimization method to evaluate the benefits of an EC along two axes: 1) self-consumption of the local ...
Alyssa D. Mustika, Rémy Rigo-Mariani, Vincent Debusschere, Amaury Pachurka   +3 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Autophagy in toxicology: self‐consumption in times of stress and plenty [PDF]

Journal of Applied Toxicology, 2012
ABSTRACTAutophagy is a critical cellular process orchestrating the lysosomal degradation of cellular components in order to maintain cellular homeostasis and respond to cellular stress. A growing research effort over the last decade has proven autophagy to be essential for constitutive protein and organelle turnover, for embryonic/neonatal survival and
Alicia M, Bolt, Walter T, Klimecki
openaire   +2 more sources

Extrativismo e Produção de Alimentos como Estratégia de Reprodução de Agricultores Familiares do Assentamento Seringal, Amazônia Meridional

Revista de Economia e Sociologia Rural
Resumo: A soberania alimentar do agricultor familiar está relacionada à transformação do agroecossistema, articulando a geração de trabalho e renda e sua capacidade de autoprodução de alimentos. Assim, este trabalho tem por objetivo investigar a produção
Keller Regina Soares, Esvanio Edipo da Silva Ferreira, Santino Seabra Junior, Sandra Mara Alves da Silva Neves   +3 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

The New Spanish Self-consumption Regulation

Energy Procedia, 2016
Abstract The new Spanish Power Sector Law (Ley del Sector Electrico, LSE) 24/2013 regulates self-consumption facilities for the first time, and in particular domestic PV panels. The paper analyzes the approved regulation. It is concluded that energy prices and access tariffs should faithfully reflect actual supply costs, in order not to distort ...
Aragonés, Vanessa, Barquín, Julián, Alba, Juan   +2 more
openaire   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source