Results 71 to 80 of about 75,871 (297)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mental health attitudes, self-criticism, compassion and role identity among UK social work students.

, 2018
Although many social work students suffer from mental health symptoms, the majority of them do not seek help, because of shame. Accordingly, the purposes of this study were to evaluate social work students' attitudes for mental health problems, and ...
Sheffield, David, Green, Pauline Catherine, Kotera, Y.   +2 more
core   +1 more source

Personality and cognitive processes: self-criticism and different types of rumination as predictors of suicidal ideation [PDF]

, 2008
Self-criticism and rumination have been related to suicidality. In the present study, we investigated the extent to which different types of rumination (brooding and reflection) mediate the relationship between self-criticism and suicidal ideation.
Rory C. O’Connor, O'Connor, Rory, Noyce, Rosie, Rosie Noyce   +3 more
core   +1 more source

New instability and symmetry: criticism and Neobaroque’s self-criticism

Gragoatá, 2006
This essay proposes an interpretation of the neobaroque from the perspective of the work of its main poet-thinkers: the Brazilian Haroldo de Campos, the French-Cuban Severo Sarduy and the Argentinean Arturo Carrera. Aiming at providing a criticism of the
Joca Wolff
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Effectiveness of Emotion Focused Therapy on Alexithymia and Internalized Self-Criticism in Neurotic Perfectionist Girls [PDF]

Taḥqīqāt-i ̒Ulūm-i Raftārī, 2023
Aim and Background: The aim of the current study was to investigate the effectiveness of Emotion Focused Therapy on Alexithymia and Internalized Self-Criticism in Neurotic Perfectionist girls.
Zahra Khadem Dezfuli, Seyedeh Zahra Alavi, Masoud Shahbazi   +2 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Self-criticism self-report measures: Systematic review [PDF]

, 2018
PurposeSelf-criticism is a transdiagnostic process that has been attracting research and clinical interest. The accurate measurement of this construct is therefore crucial, however, there are currently numerous measures of self-criticism and no ...
Katharine A. Rimes, Rose, Alexandra V., Rimes, Katharine A.; id_orcid, Alexandra V. Rose   +3 more
core   +1 more source

The relationship between reinforcement sensitivity and non-suicidal self-injury among adolescents: moderated mediation effect

Frontiers in Psychology
ObjectiveNon-suicidal self-injury (hereinafter referred to as NSSI) is a significant public health concern among adolescents. Understanding its underlying psychological mechanisms is crucial for developing effective interventions. This study explored how
Rong Kong, Ruihua Chen, Tingyu Hou, Na Li   +3 more
doaj   +1 more source