Results 81 to 90 of about 75,871 (297)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Negative self-referential emotions and mental health in youth: The importance of self-criticism.

, 2021
There are many measures available that survey positive and negative emotional indicators of wellbeing in children and adolescents (Žukauskienė et al, 2015).
Stupple, E., Barnes, C., Ashra, H., Maratos, F.   +3 more
core   +1 more source

The Impact of Shame, Self-Criticism and Social Rank on Eating Behaviours in Overweight and Obese Women Participating in a Weight Management Programme. [PDF]

PLoS ONE, 2017
Recent research has suggested that obesity is a stigmatised condition. Concerns with personal inferiority (social rank), shame and self-criticism may impact on weight management behaviours.
Cristiana Duarte, Marcela Matos, R James Stubbs, Corinne Gale, Liam Morris, Jose Pinto Gouveia, Paul Gilbert   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A multidimensional approach to self-criticism: development of the self-criticism scale and investigation of its psychometric properties

, 2022
The aim of this research is to develop a scale to determine the self-criticism levels of adults and to examine their psychometric properties. This study, using quantitative research methods, was conducted with 675 adults (18-61 years old) (xm: 25.95; xsd:
EKŞİ, HALİL
core   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Randomised Controlled Trial of an Online Version of Compassion Mind Training in a Nonclinical Sample

Europe's Journal of Psychology, 2020
Compassion Mind Training (CMT) is a therapeutic approach to guide highly self-critical individuals to generate compassion. The goal was to probe the efficacy of a short-term, online version of the CMT on self-compassion and self-criticism in a non ...
Júlia Halamová, Martin Kanovský, Alexandra Pačutová, Nuriye Kupeli   +3 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Growing Up with a Narcissistic Mother: Mediating Role of Self-Criticism in the Relationship of Maternal Narcissistic Traits with Depression and Anxiety

Psikiyatride Güncel Yaklaşımlar
Objective: This study aims to examine the mediating role of self-criticism in the relationship between narcissistic traits perceived from the mother in childhood and symptoms of depression and anxiety disorders in adulthood.
Emre Han Alpay, Arzu Aydın
doaj   +1 more source