Self-Criticism and Self-Compassion in Adolescents: Two Forms of Self-Relating and Their Implications forPsychopathology and Treatment [PDF]
, 2017 Different ways of relating to oneself are linked with distinctive mental health outcomes: shame and self-criticism underpin a variety of psychological disorders, while self-compassion stands as a resource or protective factor related to psychological ...
Castilho, Paula +3 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Self-Criticism Intervention Modules
, 2023 Intervention modules developed to disrupt the relationship between use of social media and disordered eating by reducing self-criticism.
Madelaine de Valle (14394351) +1 more
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
The Development and Validation of the Adolescent Self-Criticism Scale (ASCS) [PDF]
Background In adolescence, self-criticism represents a central phenomenon in a variety of mental disorders, and can portend emotional, social, and behavioural problems.
Stupple, E. +3 more
core +1 more source
Self‐criticism and self‐reassurance as mediators between mental health attitudes and symptoms: Attitudes toward mental health problems in Japanese workers [PDF]
, 2018 Japanese workers suffer high rates of mental health symptoms, recognised recently by the Japanese government, which has enacted workplace well-being initiatives.
Paul Gilbert +9 more
core +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Actors and Vehicles of Architectural Criticism (12)
, 2016 Among Criticism, Design and Photography. A Literary and Photographic Way for the Criticism in Shared Works by Vittorio Savi, Aldo Rossi and Luigi Ghirri (1972-1989) Matteo Cassani Simonetti University of Bologna Shared works by the critic Vittorio Savi ...
Mapping Architectural Criticism
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source