Results 51 to 60 of about 6,332,646 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Creating Security and Stability in Afghanistan and the Region

, 2006
Recommendations in this report address issues related to ongoing state-building efforts in Afghanistan in the areas of security, rule of law, mobilization of the economy, regional relations, and trans-border issues including infrastructure and energy ...
Liechtenstein Institute on Self-Determination
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pengaruh Peran Ayah (Fathering) terhadap Determinasi Diri (self Determination) Remaja

Psikoislamika, 2019
Tujuan dalam penelitian ini adalah untuk mengetahui apakah peran ayah berpengaruh terhadap determinasi diri pada remaja kelas X di SMAN 3 Malang. Responden dalam penelitian ini berjumlah 108 orang dengan 54 orang laki-laki dan 54 perempuan.
Leli Nailul Muna, Elok Halimatus Sakdiyah   +1 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The Problem of Personal Self-Determination in L. I. Bozhovich’s Works and its Development from the Viewpoint of the Subject-Centered Approach

Психолого-педагогические исследования, 2018
The article analyzes the understanding of self-determination in L. I. Bozhovich’s works, authors present the theoretical context in which self-determination was considered in her researches (development of personality as the mastering of the behavior ...
Ermolaeva M.V., Lubovsky D.V. , Silaeva L.V.   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Perceptions of self-determination and quality of life among Swedish home care recipients - a cross-sectional study

BMC Geriatrics, 2019
Background It is acknowledged that preservation of self-determination is very important in order for older adults to experience good quality of life, but to what degree and in what areas people receiving help from home care service experience self ...
Karin Bölenius, Kristina Lämås, Per-Olof Sandman, Marie Lindkvist, David Edvardsson   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source