Results 71 to 80 of about 4,502,505 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Building State and Security in Afghanistan and the Region

, 2005
This report compiles materials related to the Liechtenstein Institute on Self-Determination¿s project, ¿Promoting Stability and Viability in Afghanistan and the Region,¿ which began in 2001 and ran through summer 2005, and considered the future of ...
Liechtenstein Institute on Self-Determination
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

THE OPPORTUNITIES OF INTERNET ENVIRONMENT OF CYBERSPACE FOR PERSONAL SELF-DETERMINATION OF YOUTH

Sovremennye Issledovaniâ Socialʹnyh Problem, 2017
The study was conducted in the context of personal self-determination of youth in the process of cybersocialization, which proceeds under influence and as a result of the using of modern Information-communication technologies. And this problem is the one
Tatiana Valentinovna Obidina
doaj   +1 more source

Self-determined or non-self-determined? Exploring consumer motivation for sustainable food choices

Sustainable Production and Consumption
Agricultural production is one of the major sources of greenhouse gas emissions with livestock farming accounting for half of the mitigation potential of greenhouse gas emissions of agriculture, forestry, and land-use sectors. Hence, a sustainable transition of the agricultural sector is urgently needed to achieve the objectives outlined in the Paris ...
Schulze, Maureen, Janssen, Meike
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Conjuring up the correspondence of high-school students’ self-determination and classroom climate with reading achievement

English Language Teaching Educational Journal, 2020
A prevalent goal of education in schools is reading comprehension enhancement. Therefore, a critical issue in   educational psychology is investigating the factors contributing to increase the reading achievement including both classroom climate and ...
Shahrbanoo Joulide, Akram Faravani, Ali Akbar Boori   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Self-Determination Theory. Characteristics and applications [PDF]

, 2023
openLa Self-Determination Theory (SDT), o Teoria dell'Autodeterminazione, è un approccio teorico ampiamente studiato nell'ambito della psicologia della motivazione e del benessere. Sviluppata da Edward L. Deci e Richard M.
CORNACCHIONE, DANIELE
core  

PROFESSIONAL SELF-DETERMINATION AS A SOCIAL AND CULURAL PROCESS

Вестник Кемеровского государственного университета, 2014
Professional self-determination is an important factor of socialization and self-identity not only in a specific professional field. The paper analyzes the essence of professional self-determination based on an integrated multidisciplinary approach ...
I. A. Levitskaya
doaj