Results 71 to 80 of about 6,332,646 (291)

PROFESSIONAL SELF-DETERMINATION AS A SOCIAL AND CULURAL PROCESS

Вестник Кемеровского государственного университета, 2014
Professional self-determination is an important factor of socialization and self-identity not only in a specific professional field. The paper analyzes the essence of professional self-determination based on an integrated multidisciplinary approach ...
I. A. Levitskaya
doaj  

Zombie Self-determination?

Review of Central and East European Law
Völkerrechtsblog
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Self-Determination Right of Indigenous Peoples

Московский журнал международного права, 2010
Self-Determination Right is still an object of dispute among international jurists. It often becomes a stumbling block and leads to inter-ethnic conflicts.
R. S. Garipov
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Summary Report: Afghanistan Implementation Colloquium

, 2010
The report suggests that perceptions and lack of trust are key issues complicating governance reform in Afghanistan and the transfer of responsibilities for security and development from the international community to the Afghan government.
Liechtenstein Institute on Self-Determination
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A New Vision for Afghanistan

, 2008
The report assesses progress made and addresses critical issues facing Afghanistan in the areas of security, regional relations, elections, governance and rule of law, the economy and human development, and policy in the region and macro region.
Liechtenstein Institute on Self-Determination
core  

Phenomenological Insights into Self-Determination Among Saudi Employed Adults with Intellectual Disabilities

مجلة التربیة الخاصة والتأهیل
This qualitative phenomenological study examines the lived experiences of six Saudi-employed adults with mild intellectual disabilities (ID) who received self-determination interventions during high school transition planning.
عبدالرحمن الزارع
doaj   +1 more source