Results 81 to 90 of about 4,502,505 (302)

Self-Determination Right of Indigenous Peoples

open access: yesМосковский журнал международного права, 2010
Self-Determination Right is still an object of dispute among international jurists. It often becomes a stumbling block and leads to inter-ethnic conflicts.
R. S. Garipov
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Psychological potential of personal self-realization

open access: yesSocial Welfare: Interdisciplinary Approach, 2016
The article reveals the psychological foundations of the self-realization phenomenon. It shows that personal self-realization as a self-determined phenomenon is determined by a complex of interconnected personal indicators, including the value of self ...
Sergiy Maksimenko, Liudmyla Serdiuk
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Summary Report: Afghanistan Implementation Colloquium

open access: yes, 2010
The report suggests that perceptions and lack of trust are key issues complicating governance reform in Afghanistan and the transfer of responsibilities for security and development from the international community to the Afghan government.
Liechtenstein Institute on Self-Determination
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Phenomenological Insights into Self-Determination Among Saudi Employed Adults with Intellectual Disabilities

open access: yesمجلة التربیة الخاصة والتأهیل
This qualitative phenomenological study examines the lived experiences of six Saudi-employed adults with mild intellectual disabilities (ID) who received self-determination interventions during high school transition planning.
عبدالرحمن الزارع
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

A New Vision for Afghanistan

open access: yes, 2008
The report assesses progress made and addresses critical issues facing Afghanistan in the areas of security, regional relations, elections, governance and rule of law, the economy and human development, and policy in the region and macro region.
Liechtenstein Institute on Self-Determination
core  

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