Results 41 to 50 of about 9,224 (198)

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

The rapid appearance of homostyly in a cultivated distylous population of Primula forbesii

Ecology and Evolution, 2022
Evolutionary breakdown from rigorous outbreeding to self‐fertilization frequently occurs in angiosperms. Since the pollinators are not necessary, self‐compatible populations often reduce investment in floral display characteristics and pollination reward.
Cai‐Lei Liu, Yin Jia, Yi‐Feng Li, Yuan‐Fen Xiang, Yuan‐Zhi Pan, Qing‐Lin Liu, Ke‐Hang Ma, Xian‐Cai Yin   +7 more
doaj   +1 more source

Spontaneous Cyclic Levitation of Glycerol‐Water Droplets at Low Pressures

Advanced Science, EarlyView.
Under low pressure, a minute glycerol addition transforms the chaotic dynamics of freezing water droplets into cyclic levitation. Freeze‐concentration preserves liquid pathways that relax expansion‐induced stress, while freezing point depression weakens asymmetric vaporization recoil.
Chen Xu, Renjie Hua, Wei Ma, Fuqiang Chu, Dong Liang, Xueshi Li, Qirui Zhang, Yuan Dong, Xuehu Ma, Xiao Yan, Shuhuai Yao   +10 more
wiley   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Women’s attitude towards representation of women domestication in advertisement

Masyarakat, Kebudayaan dan Politik, 2019
The persuasive strategies in advertising often use gender-biased signs or languages, which represent women’s subordination and domestication. On the other hand, the construction and development of individual gender concepts begin in childhood through the
Endah Siswati
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Intra- and inter-specific reproductive barriers in the tomato clade

Frontiers in Plant Science, 2023
Tomato (Solanum lycopersicum L.) domestication and later introduction into Europe resulted in a genetic bottleneck that reduced genetic variation.
Pauline Moreels, Servane Bigot, Corentin Defalque, Francisco Correa, Juan-Pablo Martinez, Stanley Lutts, Muriel Quinet   +6 more
doaj   +1 more source

‘I was treated as a deficit’: Immigrant teachers' career progression in Australia

British Educational Research Journal, EarlyView.
Abstract Immigrant teachers have long been recruited through skilled and employer‐sponsored migration schemes to address teacher shortages in Australia, yet their career trajectories remain constrained by systemic inequities that limit their integration and professional development opportunities.
Ching Ting Tany Kwee, Hoa Thi Mai Nguyen, Tony Loughland   +2 more
wiley   +1 more source

Paedomorphic facial expressions give dogs a selective advantage.

PLoS ONE, 2013
How wolves were first domesticated is unknown. One hypothesis suggests that wolves underwent a process of self-domestication by tolerating human presence and taking advantage of scavenging possibilities.
Bridget M Waller, Kate Peirce, Cátia C Caeiro, Linda Scheider, Anne M Burrows, Sandra McCune, Juliane Kaminski   +6 more
doaj   +1 more source