Results 91 to 100 of about 290,159 (337)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Multidimensional quasi-twisted codes : equivalent characterizations and their relation to multidimensional convolutional codes [PDF]

open access: yes, 2019
We study multidimensional analogues of quasi-twisted codes from different points of view. Their concatenated structure allows us to characterize self-dual and complementary-dual classes of such codes as well as to show that multidimensional quasi-twisted
Özkaya, Buket, Ling, San
core   +1 more source

Genetic Algorithm-Based Method for Discovering Involutory MDS Matrices

open access: yesComputational and Mathematical Methods, 2023
In this paper, we present an innovative approach for the discovery of involutory maximum distance separable (MDS) matrices over finite fields F2q, derived from MDS self-dual codes, by employing a technique based on genetic algorithms. The significance of
El Mehdi Bellfkih   +4 more
doaj   +1 more source

On involutions in extremal self-dual codes and the dual distance of semi self-dual codes

open access: yesFinite Fields and Their Applications, 2015
12 ...
Martino Borello, Gabriele Nebe
openaire   +3 more sources

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Self-dual Codes Using Image Restoration Techniques [PDF]

open access: yes, 2001
From past literature it is evident that the search for self-dual codes has been hampered by the computational difficulty of generating the Hadamard matrices required. The use of the cocyclic construction of Hadamard matrices has permitted substantial cut-
Joselito Chua (20010360)   +1 more
core  

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian   +4 more
wiley   +1 more source

An upper bound for self-dual codes

open access: yesInformation and Control, 1973
Gleason has described the general form that the weight distribution of a self-dual code over GF(2) and GF(3) can have. We give an explicit formula for this weight distribution when the minimum distance d between codewords is made as large as possible. It follows that for self-dual codes of length n over GF(2) with all weights divisible by 4, d ⩽ 4[n/24]
Colin L. Mallows, Neil J. A. Sloane
openaire   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

open access: yesArthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin   +14 more
wiley   +1 more source

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