Results 151 to 160 of about 112,755 (263)

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

open access: yesAdvanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang   +4 more
wiley   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

open access: yesAdvanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet   +11 more
wiley   +1 more source

Biocompatible Conjugated Electrospinning Nanofibrous Membrane With Self‐Powered Piezoelectric Capacity for Accelerated Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
A self‐powered PCL/gelatin‐PVDF‐TrFE/MXene conjugated electrospun membrane integrates biocompatibility with enhanced piezoelectric responsiveness. Mechanical deformation is converted into localized electrical signals that stimulate wound‐repair cells proliferation and migration, promote angiogenesis and tissue remodeling, and accelerate full‐thickness ...
Diandian Li   +11 more
wiley   +1 more source

A 3D‐Printed Model of Human Lactation

open access: yesAdvanced Healthcare Materials, EarlyView.
Breastfeeding supports infant and maternal health, yet in vitro models that mimic human lactation remain scarce. Here, light‐based 3D printing creates high‐resolution, alveoli‐inspired microwells that guide breast cells into polarized microtissues. The printed scaffolds embed slow‐release prolactin microcrystals to deliver hormonal cues, enabling human
Amelia Hasenauer, Marcy Zenobi‐Wong
wiley   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

open access: yesAdvanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng   +10 more
wiley   +1 more source

Brief speech samples reveal emotional states in daily life. [PDF]

open access: yesPNAS Nexus
Koch TK   +6 more
europepmc   +1 more source

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