Results 51 to 60 of about 3,910,063 (300)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Self-Employment in the News Industry
, 2023 This chapter highlights the position of freelance or self-employed journalists in the news sector from the pessimistic observation that news organizations tend to push journalists into a freelance status to cope with decreasing revenues and are inspired by neoliberal thoughts.
Van Leuven, Sarah, Vandenberghe, Hanne
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Self-Employment and Entrepreneurship: A Theoretical Approach
Journal of Management and Business Administration, Central Europe, 2018 Purpose: The purpose of this article is to position self-employment within an entrepreneurship paradigm. The authors create a structured approach to the existing concepts and definitions of entrepreneurship and self-employment, as well as interrelations ...
Jolanta Szaban +1 more
doaj +1 more source
Consequences of employment self–etching primer adhesive in orthodontic practice [PDF]
Al-Rafidain Dental Journal, 2004 The purposes of this study were to evaluate the shear bonding strength of stainless steel brackets bonded with self–etching primer adhesive system (Trans-bondTM 3M Uniteck, Monrovia, California, USA), compared with same system which employ 35% phosphoric
Ali R Al–Khatib
doaj +1 more source
IT Self-Employment: A Protean Career View
Proceedings of the 2023 Computers and People Research Conference on ZZZ, 2023 IT self-employment is a growing trend. IS research however has mostly focused on careers of IT professionals in an organizational context. In this study, we use the Protean Career perspective to investigate reasons for the transition of IT professionals from organizational to self-employment in IT.
Faheem Ahmed Shaikh +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Self vs. Organizational employment: The neglected case of positive spillover [PDF]
New England Journal of Entrepreneurship, 2012 Self-employment is presented as enabling people to better balance their work and family roles but research on its effectiveness is equivocal. We collected survey data from 280 self- and organizationally-employed certified public accountants and conducted
David J. Prottas
doaj +1 more source
Occupational Choice and Self-Employment — Are They Related? [PDF]
SSRN Electronic Journal, 2013 Often, a person will become an entrepreneur only after a period of dependent employment, suggesting that occupational choices precede entrepreneurial choices. We investigate the relationship between occupational choice and self-employment. The findings suggest that the occupational choice of future entrepreneurs at the time of labor market entry is ...
Alina Sorgner, Michael Fritsch
openaire +4 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source