Results 51 to 60 of about 5,650,588 (306)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The glass cage: The gender pay gap and self-employment in the United States [PDF]

New England Journal of Entrepreneurship, 2016
Self-employment is often viewed as a more desirable work arrangement than working as an employee for a firm. Women are pushed into self-employment due to organizational factors, such as a shrinking workforce or limited job opportunities, while being ...
Leanna Lawter, Tuvana Rua, Jeanine Andreassi   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Comparative Approach to Explore the Effects of Institutions on Self-Employment and Innovation in Selected Countries [PDF]

Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2012
In this paper, we try to explain cross-country differences in the level of entrepreneurship using self-employment and innovation as proxy variables. For this purpose, we use a comparative approach to explore empirically the ways in which institutions ...
Saeid Eisa Zade, Jahan Bakhsh Mehranfar, Mahdi Ferdosi   +2 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Self-Employment Dynamics and Self-Employment Trends: A Study of Canadian Men and Women, 1982-1995. [PDF]

Self-employment has risen dramatically in Canada, accounting for a disproportionate share of job growth since the 1980's. Using hitherto-unexploited information on labour force transitions from 13 waves of the Survey of Consumer Finances between 1982 and
Herbert Schuetze, Peter Khun
core   +2 more sources

Is self-employment an antidote to poverty in developing countries? Insights from a cross-sectional study in Ghana

Cogent Economics & Finance
Despite numerous policies implemented in this respect, Ghana still needs to catch up in achieving the Sustainable Development Goal of ending poverty in all forms by 2030.
Kwame Adjei-Mantey, Mark Edem Kunawotor
doaj   +1 more source

Self-Employment and Entrepreneurship: A Theoretical Approach

Journal of Management and Business Administration, Central Europe, 2018
Purpose: The purpose of this article is to position self-employment within an entrepreneurship paradigm. The authors create a structured approach to the existing concepts and definitions of entrepreneurship and self-employment, as well as interrelations ...
Jolanta Szaban, Małgorzata Skrzek-Lubasińska   +1 more
doaj   +1 more source

Occupational Choice and Self-Employment — Are They Related? [PDF]

SSRN Electronic Journal, 2013
Often, a person will become an entrepreneur only after a period of dependent employment, suggesting that occupational choices precede entrepreneurial choices. We investigate the relationship between occupational choice and self-employment. The findings suggest that the occupational choice of future entrepreneurs at the time of labor market entry is ...
Alina Sorgner, Michael Fritsch
openaire   +4 more sources