Results 91 to 100 of about 312,148 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why Condition-Based Regression Analysis (CRA) is Indeed a Valid Test of Self-Enhancement Effects: A Response to Krueger et al. (2017)

Collabra: Psychology, 2018
How can the consequences of self-enhancement (SE) be tested empirically? Traditional two-step approaches for investigating SE effects have been criticized for providing systematically biased results.
Sarah Humberg, Michael Dufner, Felix D. Schönbrodt, Katharina Geukes, Roos Hutteman, Maarten H. W. van Zalk, Jaap J. A. Denissen, Steffen Nestler, Mitja D. Back   +8 more
doaj   +1 more source

Value Orientation, Awareness of Consequences, and Environmental Concern [PDF]

, 2011
The tenets of the value-basis approach to environmental concern are (i) that environmental concern is motivated by beliefs about adverse egoistic (e.g., own health), social-altruistic (e.g., peoples’ health), and biospheric consequences of environmental ...
Hansla, André
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Magic mirror on the wall: Selfie-related behavior as mediator of the relationship between narcissism and problematic smartphone use [PDF]

, 2019
Objective: Recent research has suggested that problematic smartphone use is associated with several psychological factors and that mobile apps and smartphone-related behavior (i.e. selfi e behavior) may encourage the development of problematic smartphone
Cavani P., Di Blasi M., Giordano C., Lo Coco G., Pavia L., Salerno L., Tosto C.   +6 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The Slow Decay and Quick Revival of Self-Deception

Frontiers in Psychology, 2015
People demonstrate an impressive ability to self-deceive, distorting misbehavior to reflect positively on themselves—for example, by cheating on a test and believing that their inflated performance reflects their true ability.
Zoe eChance, Francesca eGino, Michael I. Norton, Dan eAriely   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

I’m not the person I used to be: The self and autobiographical memories of immoral actions [PDF]

, 2017
People maintain a positive identity in at least two ways: They evaluate themselves more favorably than other people, and they judge themselves to be better now than they were in the past. Both strategies rely on autobiographical memories.
De Brigard, Felipe, Henne, Paul, Iyengar, Vijeth, Sinnott-Armstrong, Walter, Stanley, Matthew L.   +4 more
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source