Results 81 to 90 of about 312,148 (308)
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Higher-Order Defeat Without Epistemic Dilemmas [PDF]
, 2018 Many epistemologists have endorsed a version of the view that rational belief is sensitive to higher-order defeat. That is to say, even a fully rational belief state can be defeated by misleading higher-order evidence, which indicates that the belief ...
Skipper, Mattias
core
Organizational Images And Member Identification [PDF]
, 1994 We develop a model to explain how images of one's work organization shape the strength of his or her identification with the organization. We focus on two key organizational images: one based on what a member believes is distinctive, central, and ...
Dukerich, J. M. +2 more
core +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Narcissism in Public Accounting Firms [PDF]
, 2014 Similar to other characteristics, narcissism is a personality trait that varies by individuals. While the management literature has examined narcissism, there is limited research of narcissism of professionals in public accounting firms.
Akers, Michael D. +2 more
core +2 more sources
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
On the Existential Road From Regret to Heroism: Searching for Meaning in Life
Frontiers in Psychology, 2018 We investigated whether regret predicted the motivation to act heroically. In a series of studies, we examined the relationship between regret, search for meaning in life, and heroism motivation.
Eric R. Igou +3 more
doaj +1 more source
Advertising and Culture: Variations on the Theme of Individualism in Korean and American Magazine Advertising [PDF]
, 2000 Social scientists regard the U.S. and the Republic of Korea as countries with opposing cultural values. Given this contrast, the advertising of each culture is expected to differ.
Kim, Hoh, Wolburg, Joyce M.
core +1 more source
Unmotivated or motivated to fail? A cross-cultural study of achievement motivation, fear of failure, and student disengagement [PDF]
, 2016 A classic distinction in the literature on achievement and motivation is between fear of failure and success orientations. From the perspective of self-worth theory, these motives are not bipolar constructs but dimensions that interact in ways that make
Byrne, Donald +2 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source