Results 51 to 60 of about 60,142 (255)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
What is the best grid-map for self-driving cars localization? An evaluation under diverse types of illumination, traffic, and environment [PDF]
, 2021 Filipe Mutz +6 more
openalex +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Investigación y Postgrado, 2005 La presente investigación forma parte de un proyecto de mayor alcance acerca del uso del portafolio en la enseñanza de lenguas extranjeras. Tiene como objetivos: (1) describir cómo es percibida esta estrategia de trabajo/evaluación desde la perspectiva ...
Ana Lucía Delmastro
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Ability of Non-Music Majors to Self-Evaluate at the End of a Music Course
Journal of Educators Online, 2016 The researchers of this study investigated the participants’ (N = 177) use of a self-evaluation tool employed at the end of an online undergraduate music course that fulfilled the Texas general education requirement for the creative arts.
Dan Keast, Larke Tapper
doaj
SELF-EVALUATION OF GAMBELLA UNIVERSITY
International Journal of Research -GRANTHAALAYAH, 2018 The major objective of this study was to investigate the quality of education, research and service delivery in Gambella University. To realize this objective, the summary write up was deployed the qualitative presentation of data and statistical records presentation of certain data of numerical values.
Tamrat Dina Teresa +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Prediction of risk for boys' involvement in drug use based on levels of self-evaluations in Russia
Indian Journal of Psychological Medicine, 2017 Background: Adolescents often experiment with drug use, which can impact on their health and well-being and increase the probability of problem drug use. Yet, not enough is known about which psychological indicators is related with the initiation of drug
Svetlana N Islamova, Rafael Sh Islamov
doaj +1 more source