Results 101 to 110 of about 3,434,444 (317)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Influence of Calcium-Based Whisker Self-Healing Agent on Self-Healing of Oil Well Set Cement Cracks in CCUS Wells

Zuanjingye yu wanjingye
In wells for carbon capture, utilization and storage (CCUS), cement sheaths are easy to get chemically damaged, hence reducing their service life. A study was conducted to enhance the self-healing capacity of cement sheaths by reacting calcium-based ...
Hongchang CAO, Donghong DANG, Ye ZHANG, Qiang REN, Jingli LIU, Yan LIU, Song PENG, Jun MA   +7 more
doaj   +1 more source

Self-healing Properties of Engineered Cementitious Composites (ECC)

, 2020
Concrete is the most widely used construction material globally; however, its brittle behavior makes it prone to cracking, negatively impacting the structural durability and sustainability of concrete infrastructure.
Mahmoodi, Sina
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Humidity‐Induced Self‐Oscillating and Self‐Healing Hypercrosslinked Metal–Organic Polyhedra Membranes

Advanced Science
Designing autonomously oscillating materials is highly desirable for emerging smart material fields but challenging. Herein, a type of hypercrosslinked metal–organic polyhedra (HCMOPs) membranes formed by covalent crosslinking of boronic acid‐modified Zr‐
Jiamin Li, Zhaoyi Liu, Jinjin Liu, Xue Liu, Yang Luo, Jiajie Liang, Zhenjie Zhang   +6 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

An Equivalent Circuit Model for Lithium Battery of Electric Vehicle considering Self-Healing Characteristic

Journal of Control Science and Engineering, 2018
Considering the self-healing phenomenon of lithium batteries during intermittent discharge, a self-healing characteristic-based equivalent circuit model of lithium batteries is proposed.
Zhaodi Pei, Xiaoxu Zhao, Huimei Yuan, Zhen Peng, Lifeng Wu   +4 more
doaj   +1 more source

Healing for Our Stolen Generations: sharing our stories

, 2016
Executive summary This report is a review of the first two years of projects funded under the Healing Foundation’s Stolen Generations Initiative 2013-2015.
Healing Foundation
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Solvent-based self-healing polymeric materials

, 2010
Mechanical damage to bulk polymers typically begins as a microcrack, which can lead to eventual failure of the material if there is no method to inhibit crack growth. In living systems, this damage automatically initiates a healing response.
Caruso, Mary M.
core