Results 71 to 80 of about 1,586,496 (273)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
PERMITTED SELF-HELP AS AN INSTRUMENT OF PROPERTY PROTECTION
Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2016 The paper indicates instruments of possession protection as well as description of their distinctive or dependent character. The differences between an owner-like and a subsidiary owner have been defined.
Dariusz Trendel
doaj +2 more sources
GUIDED SELF-HELP IN THE TREATMENT OF COMMON MENTAL HEALTH DISORDERS – THE DEVELOPMENT OF THE FINNISH GUIDED SELF-HELP (F-GSH) MODEL [PDF]
Psychiatria FennicaIncreasing access to short-term, evidence-based psychological therapies in primary care or community-based settings is a key strategy for responding to the rapid increase of demand for mental health services seen in most Western countries.
KASPERI MIKKONEN, ALESSANDRA BOMBINO, ALEX VILLA, SARA NURMINEN, REETTA-MARIA ROIHA, PASI ROSLUND, JAN-HENRY STENBERG, JESPER EKELUND, SUOMA E. SAARNI, SAMULI SAARNI
doaj
Yixue yu zhexueTraditional Chinese painting has long adhered to the artistic spirit and creative approach of "freehand brushwork". This strengthens the subjectivity of painters, shifting from "spontaneous expression" to "conscious awareness", and fosters a spiritual ...
Hui LI, Henan LI, Haibin ZHANG
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Quality of life changes in an alcoholics anonymous self-help group
Socialinis Darbas: Patirtis ir Metodai, 2017 The issue of alcohol addiction is one of the most pressing in contemporary society as it causes an effect in the context of poverty, violence and suicidal behaviour.
INDRĖ DIRGĖLIENĖ +2 more
doaj +1 more source