Results 61 to 70 of about 358,075 (256)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Narrow linewidth semiconductor lasers based on nonlinear self-injection locking [PDF]

, 2023
Andrew M. Bishop, Alexander L. Gaeta
openalex   +3 more sources

Simulation Study of an LWFA-based Electron Injector for AWAKE Run 2

, 2017
The AWAKE experiment aims to demonstrate preservation of injected electron beam quality during acceleration in proton-driven plasma waves. The short bunch duration required to correctly load the wakefield is challenging to meet with the current electron ...
Doebert, Steffen, Karsch, Stefan, Muggli, Patric, Williamson, Barney, Xia, Guoxing   +4 more
core   +4 more sources

Subcutaneous formulation of belimumab in treatment of systemic lupus erythematosus: a critical review with focus on safety and satisfaction

Patient Preference and Adherence, 2018
Hamdy MA Ahmed,1–3 Samar Abohamad,2 Mohanad Elfishawi,4 Mohamed Tharwat Hegazy,2 Kadambari Vijaykumar1,5 1Internal Medicine Department, Rochester General Hospital, Rochester, NY, USA; 2Rheumatology and Clinical Immunology Unit, Internal Medicine ...
Ahmed HMA, Abohamad S, Elfishawi M, Hegazy MT, Vijaykumar K   +4 more
doaj  

Ugandan providers’ views on the acceptability of contraceptive self-injection for adolescents: a qualitative study

Reproductive Health, 2018
Background Self-injection of subcutaneous depot medroxyprogesterone acetate may offer greater discretion and increase access to injectable contraception, particularly for those who face challenges accessing clinic services.
Jane Cover, Allen Namagembe, Justine Tumusiime, Jeanette Lim, Carie Muntifering Cox   +4 more
doaj   +1 more source

Self-injected contraceptives: does the investment reflect women’s preferences?

BMJ Global Health, 2022
Subcutaneous depot medroxyprogesterone acetate (DMPA-SC) is an innovative contraceptive method aimed at meeting women’s unique circumstances and needs, largely due to its ability to be self-injected.
Sophia Magalona, Pierre Akilimali, Philip Anglewicz, Peter Gichangi, Elizabeth Omoluabi, Funmilola OlaOlorun, Georges Guiella, Shannon N. Wood, Linnea A. Zimmerman   +8 more
doaj   +1 more source

Injection tolerances and self-matching in a quasilinear wakefield accelerator [PDF]

, 2022
John Farmer, Linbo Liang, Rebecca Ramjiawan, Francesco Velotti, Martin S. Weidl, E. Gschwendtner, P. Muggli   +6 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source