Results 91 to 100 of about 9,651,619 (292)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Deliberative Democracy and the Three Inputs of Governance: Expertise, Self-Interest, and Emotions

Politeja
The idea of evidence-based policy-making is in crisis. On the one hand, it is being disrupted by agonistic partisan polarization and post-truth politics.
Michał Zabdyr-Jamróz, Elena Popa
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Support for a reciprocal effects model of self-concept and academic achievement through a contrast of multidimensional and unidimensional approaches

, 2006
There is a longstanding debate in the self-concept literature surrounding the causal ordering of self-concept and academic achievement. Some researchers have argued that self-esteem has no positive impact upon performance (Baumeister, Campbell, Krueger &
Marsh, Herbert W., O'Mara, Alison J.
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Investigating self-concept and health-related quality of life

, 2006
Health-related quality of life has been an important topic of research in diverse fields such as medicine, nursing, community service provision and psychology.
Dowson, Martin, Martin, Andrew J., Martinez, Carissa J.   +2 more
core  

From Development to Naked Self-Interest: The Doha Development Round has lost its way [PDF]

, 2005
With less than a week to go before a crucial meeting of the WTO General Council, the Doha Development Round negotiations have drifted off course. Instead of promoting the integration of developing countries in the world trading system, the 'Development ...

core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

ICT interest and self-concept as determinants of Swiss adolescents’ vocational choices

This study examines whether adolescents’ interest and self-concept regarding information and communication technologies (ICT) affect their subsequent career paths through the selection into different vocational education and training (VET) programs ...
Gomensoro, Andrés, Krebs-Oesch, Dominique, Röhlke, Leo, Herzing, Jessica M. E.   +3 more
core  

The measurement of multidimensional self-concept in adults with mild intellectual disability

, 2006
Although self-concept is now recognised as a multidimensional construct, unidimensional measurement is still common practise for adults with mild intellectual disabilities.
Craven, Rhonda, Martin, Andrew J., Dixon, Roselyn M.   +2 more
core