Results 51 to 60 of about 10,930,806 (198)
Высшее образование в России, 2019 Faith and understanding are in a complex relationship with each other; they are living in their own way in the depths of every developed human consciousness.
A. E. Razumov
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Evolution of the concept of care: cultural narratives and historical comparisons
Концепт: философия, религия, культура, 2020 The philosophy of «care» has already joined a range of problems extensively discussed by philosophers of various scholarly traditions. Exploring the concept of care as it has been defined in ancient philosophy and the philosophy of the 20th and early ...
V. V. Volodin
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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A review of the Knowledge Management Centre of the Economic and Human Development Department, City of Cape Town [PDF]
, 2012 The Knowledge Management Centre (KMC) for a municipal department was set up by a Project Consultant in 1998, with the aim of providing a largely self-service resource centre to store and distribute appropriate and up-to-date information linking to ...
UCT Knowledge Co-op
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La valeur de la connaissance des émotions
Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2019 The Value of the Emotional Knowledge Emotional knowledge is a form of self-knowledge which holds great interest for ordinary individuals. It is not obtained by any obligation but rather because we think it is crucial to obtain (Cassam 2017).
Bertille De Vlieger
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