Results 61 to 70 of about 1,497,090 (348)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Teaching mathematics : self-knowledge, pupil knowledge and content knowledge [PDF]
, 2012 Mathematical learning is significantly influenced by the quality of mathematics teaching (Hiebert and Grouws 2007). In spite of the evidence for teachers seeking to do what they believe to be in the best interests of their learners (Schuck 2009; Gholami ...
MacLellan, Effie
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Высшее образование в России, 2019 Faith and understanding are in a complex relationship with each other; they are living in their own way in the depths of every developed human consciousness.
A. E. Razumov
doaj +1 more source
Evolution of the concept of care: cultural narratives and historical comparisons
Концепт: философия, религия, культура, 2020 The philosophy of «care» has already joined a range of problems extensively discussed by philosophers of various scholarly traditions. Exploring the concept of care as it has been defined in ancient philosophy and the philosophy of the 20th and early ...
V. V. Volodin
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
What asymmetry? Knowledge of self, knowledge of others, and the inferentialist challenge [PDF]
, 2015 There is widely assumed to be a fundamental epistemological asymmetry between self-knowledge and knowledge of others. They are said to be ’categorically different in kind and manner’ (Moran), and the existence of such an asymmetry is taken to be a ...
Cassam, Quassim
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source