Results 61 to 70 of about 4,518,436 (247)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
TheoRhēma, 2022 George F. McLean is concerned in his writings with the significant changes in philosophy and theology resulting from the way humans came to see themselves and their relation to the world.
Emanuel Adin Sălăgean
doaj +2 more sources
The construction of stance in English and Arabic newspaper editorials: a case study
Humanities & Social Sciences CommunicationsThis study explores the construction of authorial stance in English and Arabic newspaper editorials. To achieve this objective, the study examines a corpus of 80 newspaper editorials retrieved from two newspapers: The first publishes in English (The ...
Sharif Alghazo +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A REFLEXIVE CONTRIBUTION ABOUT NURSING KNOWLEDGE AND NURSING CARE
Cogitare Enfermagem, 1996 The author mentions that knowing arises from the nursing’s practice down the ages, and describes Carper’s fundamental patterns of knowing. She also exposes that nursing care is seen through anthropological, philosophical, socio-psychological and ...
Lillian Daisy Gonçalves Wolff
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
SELF-MENTIONS IN APPLIED LINGUISTICS RESEARCH ARTICLES WRITTEN BY INDONESIANS AND NON-INDONESIANS
Dinamika Bahasa dan Budaya, 2019 This study explores self-mentions in Applied Linguistics research articles written by Indonesians and non-Indonesians. Twenty research articles consisting of 10 research articles written by Indonesians, and the other 10 by non-Indonesians were randomly selected from the leading and international Applied Linguistics journal published in 2017-2018.
Utomo, Slamet, Suryani, Fitri Budi
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source