Results 41 to 50 of about 788,510 (248)

Prospects of using the TVGD-02 tonometer for assisted monitoring of intraocular pressure at home

Российский офтальмологический журнал, 2021
Purpose: to evaluate the safety and convenience of self-using the intraocular pressure tonometer TVGD-02 at home with no participation of medical professionals. Material and methods. 42 people formed 30 pairs: a patient and an assistant. In 9 pairs, each
O. M. Filippova, A. M. Bessmertny, M. N. Kuzin, S. Yu. Petrov   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fault Diagnosis of Diesel Engine Valve Clearance Based on Variational Mode Decomposition and Random Forest

Applied Sciences, 2020
Diesel engines, as power equipment, are widely used in the fields of the automobile industry, ship industry, and power equipment. Due to wear or faulty adjustment, the valve train clearance abnormal fault is a typical failure of diesel engines, which may
Nanyang Zhao, Zhiwei Mao, Donghai Wei, Haipeng Zhao, Jinjie Zhang, Zhinong Jiang   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rotordynamic Evaluation of Full Scale Rotor on Tilting Pad Bearings with 0.1 and 0.3 Preload

Shock and Vibration, 2014
A system identification method for rotating machinery stability evaluation is investigated based on sine sweep excitation testing with electromagnetic actuator.
Weimin Wang, Qihang Li, Jinji Gao, Feng He, Tim Diamond, Paul Allaire   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Variational Stacked Autoencoder with Harmony Search Optimizer for Valve Train Fault Diagnosis of Diesel Engine

Sensors, 2019
Diesel engine fault diagnosis is vital due to enhanced reliability and economic efficiency requirements. The extracted features in traditional fault diagnosis are constructed manually, which is very cumbersome because of the requirement for lots of ...
Kun Chen, Zhiwei Mao, Haipeng Zhao, Zhinong Jiang, Jinjie Zhang   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source