Results 51 to 60 of about 788,510 (248)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Intelligent Diagnosis Method for Typical Co-frequency Vibration Faults of Rotating Machinery Based on SAE and Ensembled ResNet-SVM

Chinese Journal of Mechanical Engineering
Intelligent fault diagnosis is an important method in rotating machinery fault diagnosis and equipment health management. To deal with co-frequency vibration faults, a type of typical fault in rotating machinery, this paper proposes a fault diagnosis ...
Xiancheng Zhang, Xin Pan, Hao Zeng, Haofu Zhou   +3 more
doaj   +1 more source

Machinery Early Fault Detection Based on Dirichlet Process Mixture Model

IEEE Access, 2019
The most commonly used single feature-based anomaly detection method for the complex machinery, such as large wind power equipment, steam turbine generator sets, and reciprocating compressors, exhibits a defect of low-alarm accuracy due to the non ...
Bo Ma, Yi Zhao, Ying Zhang, Qing Lei Jiang, Xiu Qun Hou   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Damage evolution and toughening mechanism in brick-and-mortar structure: Essential role of interface thickness ratio

Polymer Testing
The brick-and-mortar structure, known for its excellent mechanical properties, holds significant potential in biomimetic design. However, the effect of the interface on damage evolution and toughening mechanism remains unclear.
Tian Qiu, Chengyu Guan, Lihong Liang
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Numerical and Experimental Stability Investigation of a Flexible Rotor on Two Different Tilting Pad Bearing Configurations

International Journal of Rotating Machinery, 2014
Rotordynamic stability is crucial for high performance centrifugal compressors. In this paper, the weighted instrumental variable (WIV) based system identification method for rotating machinery stability is investigated based on a sine sweep forward ...
Weimin Wang, Qihang Li, Feng He, Paul Allaire   +3 more
doaj   +1 more source

A New Fault Diagnosis Method for a Diesel Engine Based on an Optimized Vibration Mel Frequency under Multiple Operation Conditions

Sensors, 2019
The diesel engine has been a significant component of large-scale mechanical systems for the intelligent manufacturing industry. Because of its complex structure and poor working environment, it has trouble effectively acquiring the representative fault ...
Haipeng Zhao, Jinjie Zhang, Zhinong Jiang, Donghai Wei, Xudong Zhang, Zhiwei Mao   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Novel Liquid Transfer Active Balancing System for Hollow Rotors of High-Speed Rotating Machinery

Applied Sciences, 2019
With the development of high-speed rotating machinery, the unbalance vibration feature of each rotor system has a greater influence on the work efficiency, bearing life, operational time, etc.
Xin Pan, Zhen Xie, Juan Lu, Haiqi Wu, Jinji Gao, Zhinong Jiang   +5 more
doaj   +1 more source