Results 91 to 100 of about 8,265,161 (304)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Adaptive self-organization in a realistic neural network model

, 2009
Information processing in complex systems is often found to be maximally efficient close to critical states associated with phase transitions. It is therefore conceivable that also neural information processing operates close to criticality.
A. Mason, B. Barbour, Christian Meisel, E. Kandel, G. Bi, J. Barlow, J. Barrie, J. Beggs, J.-P. Pfister, M. Tsodyks, P. Isope, R. Sayer, Thilo Gross, V. Braitenberg, V. Braitenberg   +14 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Self-organization in systems of self-propelled particles

, 2000
We investigate a discrete model consisting of self-propelled particles that obey simple interaction rules. We show that this model can self-organize and exhibit coherent localized solutions in one- and in two-dimensions.In one-dimension, the self ...
A. Czirok, A. Mogilner, A. Nicol, A.S. Mikhailov, D. Helbing, E. Ben-Jacob, I. Prigogine, J. Hemmingsson, J. Toner, J. Toner, J.K. Parrish, N. Shimoyama, O.J. O’Loan, T. Vicsek, W.-J. Rappel, Y.L. Duparcmeur   +15 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Self-organization and social science

Computational and mathematical organization theory, 2017
Complexity science and its methodological applications have increased in popularity in social science during the last two decades. One key concept within complexity science is that of self-organization. Self-organization is used to refer to the emergence
D. Anzola, Peter Barbrook-Johnson, Juan I. Cano   +2 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Opto-mechanical effects in self-organization of a Bose-Einstein condensate in an optical cavity

, 2012
The influence of mirror motion on the spatial self organization of a Bose-Einstein condensate (BEC) in an optical cavity is studied. We show that the mirror dynamics tends to destroy the process of self organization. An additional external phonon pump is
Bhattacherjee, Aranya B, ManMohan, Verma, Priyanka   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Measuring Complexity in an Aquatic Ecosystem

, 2013
We apply formal measures of emergence, self-organization, homeostasis, autopoiesis and complexity to an aquatic ecosystem; in particular to the physiochemical component of an Arctic lake. These measures are based on information theory.
A. Ramírez, C. Gershenson, C. Gershenson, C. Langton, D.J. Lizcano, S.A. Kauffman   +5 more
core   +1 more source