Results 71 to 80 of about 742,475 (269)
Self-organized Segregation on the Grid [PDF]
Proceedings of the ACM Symposium on Principles of Distributed Computing, 2017 We consider an agent-based model in which two types of agents interact locally over a graph and have a common intolerance threshold $τ$ for changing their types with exponentially distributed waiting times. The model is equivalent to an unperturbed Schelling model of self-organized segregation, an Asynchronous Cellular Automata (ACA) with extended ...
Hamed Omidvar, Massimo Franceschetti
openaire +3 more sources
Motility-induced mixing transition in exponentially growing multicellular spheroids
Communications PhysicsGrowth drives cellular dynamics in dense aggregates, including bacterial colonies, developing tissues, and tumors. However, its effects on other relevant activities have not received sufficient attention.
Torben Sunkel +2 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
A Role of Constraint in Self-Organization [PDF]
, 1998 To appear in the Proc.
Domingo Soriano, Carlos +2 more
openaire +3 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Ripening and Focusing of Aggregate Size Distributions with Overall Volume Growth
Frontiers in Physics, 2014 We explore the evolution of the aggregate size distribution in systems where aggregates grow by diffusive accretion of mass. Supersaturation is controlled in such a way that the overall aggregate volume grows linearly in time. Classical Ostwald ripening,
Jürgen eVollmer +5 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source