Results 51 to 60 of about 746,459 (269)

Self-organization in the genome [PDF]

open access: yesProceedings of the National Academy of Sciences, 2009
One of the most important recent discoveries in the field of genome biology has been the demonstration that genomes are nonrandomly organized in the cell nucleus (1, 2). Examples now abound of chromosomes or genes localizing to a particular location in the nucleus or undergoing positional changes as they became activated or repressed.
openaire   +2 more sources

Self-organization of power at will

open access: yesBehavioral and Brain Sciences, 2021
Abstract We challenge and extend Ainslie's top-down view of willpower as a dual function, resolve and suppression. Instead, we propose an alternative self-organizational view of the motivational system as a network of urges, incentives, drives, and so on that interact dynamically.
openaire   +3 more sources

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger   +8 more
wiley   +1 more source

Controlling the oscillation phase through precisely timed closed-loop optogenetic stimulation: a computational study

open access: yesFrontiers in Neural Circuits, 2013
Dynamic oscillatory coherence is believed to play a central role in flexible communication between brain circuits. To test this communication-through-coherence hypothesis, experimental protocols that allow a reliable control of phase-relations between ...
Annette eWitt   +15 more
doaj   +1 more source

Guided self-organization [PDF]

open access: yesHFSP Journal, 2009
Typically, self-organization is defined as the evolution of a system into an organized form in the absence of external pressures. A broad definition of self-organization is given by Haken (2006).
openaire   +2 more sources

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris   +24 more
wiley   +1 more source

Inpatient Exposure, Confidence, and Knowledge in Pediatric Hematology/Oncology: Evaluating General Pediatric Residents During 2025 ACGME Curriculum Change

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley   +1 more source

How contact patterns destabilize and modulate epidemic outbreaks

open access: yesNew Journal of Physics, 2023
The spread of a contagious disease clearly depends on when infected individuals come into contact with susceptible ones. Such effects, however, have remained largely unexplored in the study of epidemic outbreaks. In particular, it remains unclear how the
Johannes Zierenberg   +5 more
doaj   +1 more source

Local measures enable COVID-19 containment with fewer restrictions due to cooperative effects

open access: yesEClinicalMedicine, 2021
Background: Many countries worldwide are faced with the choice between the (re)surgence of COVID-19 and endangering the economic and mental well-being of their citizens.
Philip Bittihn   +3 more
doaj   +1 more source

Sociodemographic Factors Associated With Later Stage at Diagnosis of Pediatric Germ Cell Tumors: A Report From Children's Oncology Group Registries ACCRN07 and APEC14B1

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Germ cell tumors (GCTs) often arise in the ovaries and testes (extracranial) but can also develop in the brain (intracranial). We examined the relationship of individual, family, and community‐level socioeconomic status (SES) with stage of disease at diagnosis in a cohort of pediatric patients with GCT from Children's Oncology Group
Heydon K. Kaddas   +7 more
wiley   +1 more source

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