Results 41 to 50 of about 261,223 (281)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A faster dynamic convergency approach for self-organizing maps

Complex & Intelligent Systems, 2022
This paper proposes a novel variable learning rate to address two main challenges of the conventional Self-Organizing Maps (SOM) termed VLRSOM: high accuracy with fast convergence and low topological error.
Akhtar Jamil, Alaa Ali Hameed, Zeynep Orman   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

WSOM: Building Adaptive Wavelets with Self-organizing Maps [PDF]

, 1997
The WSOM (Wavelet Self-Organizing Map) model, a neural network for the creation of wavelet bases adapted to the distribution of input data, is introduced.
Campos, Marcos, Carpenter, Gail
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Self-Organizing Maps Algorithm for Parton Distribution Functions Extraction

, 2011
We describe a new method to extract parton distribution functions from hard scattering processes based on Self-Organizing Maps. The extension to a larger, and more complex class of soft matrix elements, including generalized parton distributions is also ...
Ball R D, Del Debbio L, Del Debbio L, Evan Askanazi, Forte S, Holcomb K, Katherine A Holcomb, Lai H, Perry D Z, Peterson C, Simonetta Liuti   +10 more
core   +1 more source

Pixel Features for Self-organizing Map Based Detection of Foreground Objects in Dynamic Environments [PDF]

, 2016
Among current foreground detection algorithms for video sequences, methods based on self-organizing maps are obtaining a greater relevance. In this work we propose a probabilistic self-organising map based model, which uses a uniform distribution to ...
Domínguez, Enrique, Luque-Baena, Rafael Marcos, López-Rubio, Ezequiel, Molina-Cabello, Miguel Angel, Palomo, Esteban José   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source