Results 31 to 40 of about 490,195 (259)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Illegal print in Soviet Siberia: a brief historical essay (1921-1991)
Библиосфера, 2014 The history of the illegal press in Siberia since the creation of the Soviet state upto the USSR collapse was studied. Main tendencies of unsanctioned publishing activity in the Soviet period are characterized.
E. N. Savenko
doaj
Publishing studies: being part of a cultural practice plus x ?
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2015 In some parts of the world, Publishing Studies are a fairly well-established field of research as well as of higher education. Not least since this is not so much the case in continental Europe, the Publishing Studies community increasingly sees a more ...
Christoph Bläsi
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Modern «samizdat»: the definition
Библиосфера, 2012 The article examines the transformation of self-publishing. A comparative analysis of the key features that characterize samizdat of the Soviet and the post-Soviet period is made. The definition that reflects the essence of the modern concept of samizdat
E. N. Savenko
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2015 This issue of Libellarium features papers based on the presentations from the 2nd Publishing trends and contexts conference which took place in Pula, Croatia, on 8-9 December 2014.
Zoran Velagić
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source