Results 101 to 110 of about 1,072,525 (265)
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Cognitive Science and Spirituality
Spirituality Studies, 2019 The study provides description and discussion on research in cognitive sciences in regard to spirituality. Meditation research shows that long-term meditators can sustain high amplitude brain oscillations and phase-synchrony during meditation ...
Michal Kutáš
doaj
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Meno II: A self-referential Socratic dialogue about memory and computer programming
The ReasonerWe provide a Socratic dialogue in which Meno challenges Socrates' principle that all learning is actually the remembering of things known but forgotten.
Samuel Alexander
doaj +1 more source
Evolution of metamemory based on self-reference to own memory in artificial neural network with neuromodulation. [PDF]
Sci Rep, 2022 Yamato Y, Suzuki R, Arita T.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
O spójności (hiper)syntaktycznej i fraktalach
Stylistyka, 2010 The text consists of two parts: the first is longer and concems the much discussed links between the grammar of natural language and logie, the second - the existence o f surprising geometrical objects called fractals.
Anna Pietryga
doaj
MathematicsHow can an LLM-based agent recognize the limits of its own self-knowledge and improve that self-knowledge over time? This paper proposes the metacognitive evolutionary system (MES), a functional framework for studying metacognitive evolution at the ...
Ali Mohammad Saghiri
doaj +1 more source
A Magnetic Field SPR Sensor Based on Temperature Self-Reference. [PDF]
Sensors (Basel), 2021 Mo X, Lv J, Liu Q, Jiang X, Si G.
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source