Results 81 to 90 of about 1,139,259 (265)

Desde la calle Lucena hasta el hotel de Simbad. Sobre las identidades y la construcción del yo poético [PDF]

Impossibilia: Revista Internacional de Estudios Literarios, 2011
The aim of this paper is to give a series of theoretical approximations to the construction ofthe identity and the subject in lyric poetry. Our intention is to show that every modern lyric poem goesthrough a double process: the fictiveness of the self ...
Paula Dvorakova
doaj  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Gödelian embodied self-referential genomic intelligence: lessons for AI and AGI from the genomic blockchain

Frontiers in Robotics and AI
The security of code-based digital records is a major concern of the 21st century. AI and artificial general intelligence (AGI) can be hacked to pieces by digital adversaries, and some AI objectives can lead to existential threats. The former arises from
Sheri Markose
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Inclosures, Vagueness, and Self-Reference

Notre Dame Journal of Formal Logic, 2010
In this paper, I start by showing that sorites paradoxes are inclosure paradoxes. That is, they fit the Inclosure Scheme which characterizes the paradoxes of self-reference. Given that sorites and self-referential paradoxes are of the same kind, they should have the same kind of solution. The rest of the paper investigates what a dialetheic solution to
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Relendo a perspectividade: algumas notas sobre "o perspectivismo de Nietzsche"

Cadernos Nietzsche
Este texto contrasta o entendimento comum do "perspectivismo de Nietzsche" com o seu uso da palavra "Perspektive" e termos semelhantes. As primeiras seções proporcionam uma breve pesquisa do desenvolvimento dos diversos significados através da carreira ...
Jakob Dellinger
doaj  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source