Results 61 to 70 of about 1,040,224 (263)

Biological arrow of time: emergence of tangled information hierarchies and self-modelling dynamics

Journal of Physics: Complexity
We study open-ended evolution by focusing on computational and information-processing dynamics underlying major evolutionary transitions. In doing so, we consider biological organisms as hierarchical dynamical systems that generate regularities in their ...
Mikhail Prokopenko, Paul C W Davies, Michael Harré, Marcus G Heisler, Zdenka Kuncic, Geraint F Lewis, Ori Livson, Joseph T Lizier, Fernando E Rosas   +8 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Automatic Design and Fabrication of a Custom Ocular Prosthesis Using 3D Volume Difference Reconstruction (VDR)

IEEE Access, 2018
We have developed a new computed tomography (CT)-based 3-D volume difference reconstruction (VDR) method for building a model of soft tissue differences using facial self-referenced prototyping computation, and a computer-aided design (CAD) workflow for ...
Xin Ye, Shaoze Wang, Yan Zhu, Huifeng Shao, Lixia Lou, Dahong Qian, Juan Ye   +6 more
doaj   +1 more source

Commutativity and self-reference.

Notre Dame Journal of Formal Logic, 1982
A common occurrence in fixed point theory is the sharing of some fixed point by commuting operators. But, how common is (his occurrence in the arithmetical fixed point theory, i.e., in the theory of arithmetical self-reference? The author features the modal analysis of arithmetical self-reference as a tool to study this question and gives some ...
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Autopoiesis, la unidad de una diferencia: Luhmann y Maturana Autopoiesis, the unity of a difference: Luhmann and Maturana

Sociologias, 2003
El artículo ofrece una reseña de la fructífera relación teórica entre Niklas Luhmann y Humberto Maturana. La teoría luhmanniana es un edificio conceptual cuyas dimensiones abarcan la comprensión de todo lo social. Pese al fallecimiento del autor en 1998,
Darío Rodríguez M., Javier Torres N.
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Niklas Luhmann: a systems view of education and school improvement

Educational Futures, 2010
This paper focuses on one of the central aspects of educational theory and practice: self-reflection. The critical sociology of Niklas Luhmann is featured. Sufficient of his work is now available in translation to support an initial survey.
Derek Bunyard
doaj  

The Lord Scroop Fallacy

Informal Logic, 2000
In this paper I identify a fallacy. The fallacy is worth noting for practical and theoretical reasons. First, the rampant occurrences ofthis fallacy-especially at moments calling for careful thought-indicate that it is more pernicious to clear thinking ...
Herman E. Stark
doaj   +1 more source