Results 51 to 60 of about 1,139,259 (265)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Orders of the Division of Labor: Self-reference in Organization Structures
Journal of Organizational SociologyAs a consequence of a variety of dynamics that firms have to deal with, their structures are continually evolving. Some of the resulting patterns and structural properties, however, only become visible at a greater distance from the object of analysis ...
Meisinger Norman
doaj +1 more source
Gödel, Escher, Shakespeare y Wittgenstein ¿Qué los une? = Gödel, Escher, Shakespeare, and Wittgenstein. What relates them? [PDF]
Acta Scientiarum. Education, 2012 En este artículo se registra el proceso reflexivo seguido por los autores sobre ciertos tópicos relacionados con los procesos de cambio en ambientes sociales complejos.
Jesús López, Silvia García
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Eleutheria―Notes on Freedom between Offstage and Self-reference
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2011 In this article, Shimon Levy argues that the critical concepts used in the interpretation of Beckett's writings for the stage should emanate from the experience of the performance rather than be imposed, ready-made, from the outside.
Shimon Levy
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fractal Semiotics Modeling of Concept Cup in Religious Texts
RUDN Journal of Language Studies, Semiotics and Semantics, 2020 The article considers the concept CUP as a special fractal-semiotic object in the field of the interaction of language and culture. The relevance of the research topic is determined by the increased interest in the application of a systematic approach to
Chiung-ying Ko
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Biological arrow of time: emergence of tangled information hierarchies and self-modelling dynamics
Journal of Physics: ComplexityWe study open-ended evolution by focusing on computational and information-processing dynamics underlying major evolutionary transitions. In doing so, we consider biological organisms as hierarchical dynamical systems that generate regularities in their ...
Mikhail Prokopenko +8 more
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Characteristics of self-referred patients
Academic Medicine, 1994 This paper defines and characterizes the self-referred patient, and answers key questions about self-referred patients' access to general medical and preventive care.Five years of data (July 1987 to June 1992) from The University of Iowa Hospitals and Clinics, a 900-bed tertiary care facility, were used to identify the demographics of self-referred ...
J F, Fieselmann, M S, Hendryx
openaire +3 more sources