Results 91 to 100 of about 5,139,684 (305)
Facilitating self-regulation in higher education through self-report
For the purpose of examining a tool to enable students in higher education to systematically reflect on their own self-regulation, a modified version of the Martinez-Pons Scale of Self-Regulation was used in a cohort study of 75 first-year undergraduate ...
Maclellan, Effie, Soden, Rebecca
core +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Allured or alarmed: Counteractive control responses to food temptations in the brain
Typically, it is believed that palatable, high caloric foods signal reward and trigger indulgent responses. However, Counteractive Control Theory suggests that, to the extent that people are concerned about their weight, a confrontation with palatable ...
Stress and self-regulation +7 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Improving self-regulation can be seen as a central objective of youth psychotherapy. Five decades of psychotherapy research have produced an array of evidence-based psychotherapies (EBPs), but meta-analyses have shown that these EBPs show only a modest ...
Weisz, John
core +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Turning vice into virtue - when low self-control states facilitate goal-oriented behaviours
Despite having good intentions, people often fail to exercise self-control to act in line with their long-term goals. Research shows that even mundane circumstances such as ego-depletion, mental distraction, and hunger could all hamper self-control ...
Stress and self-regulation +2 more
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