Results 1 to 10 of about 5,141,384 (392)

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

Cell, 2007
Cancers may arise from rare self-renewing tumor-initiating cells (T-IC). However, how T-IC self renewal, multipotent differentiation, and tumorigenicity are maintained remains obscure.
Fengyan Yu, He-Rui Yao, Judy Lieberman
exaly   +2 more sources

Designing stem cell niches for differentiation and self-renewal [PDF]

Journal of the Royal Society Interface, 2018
Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in
Hannah Donnelly, M. Salmerón-Sánchez, M. Dalby   +2 more
semanticscholar   +3 more sources

SIRT1 regulates macrophage self‐renewal [PDF]

The EMBO Journal, 2017
Mature differentiated macrophages can self-maintain by local proliferation in tissues and can be extensively expanded in culture under specific conditions, but the mechanisms of this phenomenon remain only partially defined. Here, we show that SIRT1, an evolutionary conserved regulator of life span, positively affects macrophage self-renewal ability in 
Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J Busch, Jérémy Favret, Elisabeth Kowenz‐Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz, Carole Berruyer, Michael H Sieweke   +11 more
openaire   +3 more sources

Haematopoietic stem cell self-renewal in vivo and ex vivo

Nature Reviews Genetics, 2020
Adam C Wilkinson, Kyomi J Igarashi, Hiromitsu Nakauchi   +2 more
exaly   +2 more sources

Controlling pre-leukemic thymocyte self-renewal. [PDF]

PLoS Genetics, 2014
Steven Goossens, Pieter Van Vlierberghe
doaj   +5 more sources

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cell, 2017
Luisa Cimmino, Igor Dolgalev, Akihide Yoshimi   +2 more
exaly   +2 more sources

BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

Cell, 2003
Jennifer Nichols, Ian Chambers, Austin Smith   +2 more
exaly   +2 more sources

FOXM1 Maintains Homeostasis and Self-Renewal in Wharton's Jelly Mesenchymal Stem Cells. [PDF]

Genes (Basel)
Li N, Wu Q.
europepmc   +2 more sources

Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut [PDF]

eLife
Stem cell self-renewal often relies on asymmetric fate determination governed by niche signals and/or cell-intrinsic factors but how these regulatory mechanisms cooperate to promote asymmetric fate decision remains poorly understood.
Mengjie Li, Aiguo Tian, Jin Jiang
doaj   +2 more sources

MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

Nature, 2019
Vincenzo Calvanese, Fides D Lay, Gay M Crooks   +2 more
exaly   +2 more sources