Results 111 to 120 of about 5,141,384 (392)

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML [PDF]

, 2012
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently,
Armstrong, Scott A., Arreba-Tutusaus, Patricia, Bullinger, Lars, Döhner, Konstanze, Fischer, Thomas, Gaebel, Julia, Heidel, Florian H., Hirt, Carsten, Lane, Steven W., Niederwieser, Dietger, Vasioukhin, Valera, Wang, Zhu   +11 more
core   +3 more sources

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Teacher self-renewal capacity: Principal’s learning supervision strategies in elementary schools

Journal of Educational Management and Instruction
The low competency of teachers in Indonesia indicates the need to improve teacher quality through self-renewal led by principals; however, the current fulfillment of teacher needs still prioritizes quantity over quality, and many teachers face obstacles
Nahdah Nasya Sahirah, Asep Suryana, Cicih Sutarsih   +2 more
doaj   +1 more source

Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency

Stem Cell Reports, 2015
Activation of Wnt/β-catenin signaling can induce both self-renewal and differentiation in naive pluripotent embryonic stem cells (ESCs). To gain insights into the mechanism by which Wnt/β-catenin regulates ESC fate, we screened and characterized its ...
Dongbo Qiu, Shoudong Ye, Bryan Ruiz, Xingliang Zhou, Dahai Liu, Qi Zhang, Qi-Long Ying   +6 more
doaj   +1 more source

LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem-like Cells.

Cancer Research, 2018
Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood.
Chungang Liu, Limei Liu, Xue-jiao Chen, Jiamin Cheng, Heng Zhang, Chengcheng Zhang, Juanjuan Shan, Junjie Shen, C. Qian   +8 more
semanticscholar   +1 more source

Sox9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin [PDF]

, 2016
The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis.
Aldaregia, J, Aldaz, P, Arevalo, S, Bujanda, L, Carrasco-Garcia, E, Cheung, MCH, Egana, L, Garcia, I, Lopez, L, Matheu, A, Sampron, N   +10 more
core   +1 more source

Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis–Associated Uveitis or Chronic Anterior Antinuclear Antibody–Positive Uveitis

Arthritis Care &Research, EarlyView.
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Y. Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat

Cell Death Discovery
Embryonic stem cells (ESCs) exhibit unique attributes of boundless self-renewal and pluripotency, making them invaluable for fundamental investigations and clinical endeavors.
Ying Ye, Wenyan Xie, Zhaoru Ma, Xuepeng Wang, Yi Wen, Xuemei Li, Hongqian Qi, Hao Wu, Jinnan An, Yan Jiang, Xinyi Lu, Guokai Chen, Shijun Hu, Elizabeth A. Blaber, Xi Chen, Lei Chang, Wensheng Zhang   +16 more
doaj   +1 more source

Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells

PLoS ONE, 2017
Purpose Long non-coding RNAs (lncRNAs) play important roles in the malignant behavior of cancer. HOTAIR, a well-studied lncRNA, contributes to breast cancer development, and overexpression of HOTAIR predicts a poor prognosis. However, the regulatory role
J. Deng, Mengchang Yang, Rong Jiang, N. An, Xiaoshan Wang, B. Liu   +5 more
semanticscholar   +1 more source

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal [PDF]

, 2014
The gene regulatory network (GRN) that supports neural stem cell (NS cell) self-renewal has so far been poorly characterized. Knowledge of the central transcription factors (TFs), the noncoding gene regulatory regions that they bind to, and the genes ...
Ben Martynoga, Daniela Drechsel, Debbie L.C. van den Berg, Diogo S. Castro, François Guillemot, Gregory E. Crawford, Joachim Wittbrodt, Juan L. Mateo, Laurence Ettwiller, Maximilian Haeussler, Paul Flicek, Paul Robson, Q. Richard Lu, Zachary B. Gaber   +13 more
core   +1 more source