Results 131 to 140 of about 5,141,384 (392)

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal

Nature, 2017
The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear ...
Kelley S. Yan, Kelley S. Yan, C. Y. Janda, Junlei Chang, Grace X. Y. Zheng, Kathryn A. Larkin, V. Luca, Luis A. Chia, Amanda T. Mah, Arnold Han, Arnold Han, Jessica M. Terry, A. Ootani, Kelly Roelf, Mark Lee, Jenny Yuan, Xiao Li, C. Bolen, J. Wilhelmy, Paige S. Davies, Hiroo Ueno, R. Furstenberg, P. Belgrader, S. Ziraldo, H. Ordonez, S. Henning, M. Wong, M. Snyder, I. Weissman, A. Hsueh, T. Mikkelsen, K. Garcia, C. Kuo   +32 more
semanticscholar   +1 more source

Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]

, 2011
Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny, Liau, Linda M, Liu, Yue, Tso, Cho-Lea, Tso, Jonathan, Yamada, Kazunari, Ye, Fei   +6 more
core   +1 more source

Impact of Positive Lifestyle Behaviors on Direct Health Care Cost Savings for Low Back Pain

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate the relationship between a previously purpose‐developed lifestyle behavior scale and health care cost savings related to low back pain (LBP). Methods This longitudinal study used data from the Australian Twin Back (AUTBACK) study. LBP and lifestyle behavior measures were collected at baseline. Physical activity
Ye Tian, Katharine E. Roberts, Michelle Hall, Paula R. Beckenkamp, Angelo Sabag, Karoline Moe, Ana Paula Carvalho‐e‐Silva, Emily J. Callander, Paulo H. Ferreira   +8 more
wiley   +1 more source

Supplementary Figure 2 from NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells

, 2023
Filippos Kottakis, Parthena Foltopoulou, Ioannis Sanidas, Patricia J. Keller, Ania Wronski, Benjamin T. Dake, Scott A. Ezell, Zhu Shen, Stephen P. Naber, Philip W. Hinds, Elizabeth A. McNiel, Charlotte Kuperwasser, Philip N. Tsichlis   +12 more
openalex   +1 more source

Increased Lipogenesis is Critical for Self-Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega-3 Fatty Acids [PDF]

, 2021
Haiqing Luo, Chih‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinghua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing X. Kang   +9 more
openalex   +1 more source

Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons

Cell Research, 2022
Pingping Zhu, Tiankun Lu, Jiayi Wu, Dongdong Fan, Benyu Liu, Xiaoxiao Zhu, Hui Guo, Ying Du, Feng Liu, Yong Tian, Z. Fan   +10 more
semanticscholar   +1 more source

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Nature Communications, 2018
Tumors adapt their phenotypes during growth and in response to therapies through dynamic changes in cellular processes. Connexin proteins enable such dynamic changes during development, and their dysregulation leads to disease states.
P. Thiagarajan, Maksim Sinyuk, S. Turaga, Erin E Mulkearns-Hubert, J. Hale, V. Rao, A. Demelash, C. Saygin, Arnab China, Tyler J. Alban, M. Hitomi, Luke A. Torre-Healy, Alvaro G. Alvarado, A. Jarrar, Andrew C Wiechert, Valery Adorno-Cruz, P. Fox, B. Calhoun, J. Guan, Huiping Liu, O. Reizes, J. Lathia   +21 more
semanticscholar   +1 more source

Cyclin D2 is sufficient to drive β cell self-renewal and regeneration [PDF]

, 2017
Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused by autoimmune destruction (type I diabetes) or β cell failure in response to insulin resistance (type II diabetes).
Bhushan, Anil, Dhawan, Sangeeta, Field, Loren, Georgia, Senta, Tschen, Shuen-ing, Zeng, Chun   +5 more
core   +2 more sources

Accuracy of Diagnostic Codes and Algorithms Used to Identify Rheumatoid Arthritis and Juvenile Idiopathic Arthritis in Administrative Claims and Electronic Health Records: Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis and juvenile idiopathic arthritis in electronic health records. Methods We searched Medline, Embase, and Cochrane Central Register for Controlled Trials databases and included studies that validated case definitions against a ...
Constanza Saka‐Herrán, Jessica Bennett, Yara Alkabti, Muhammad Fatir, Barbara Clyne, Caroline McCarthy, Gráinne Tynan, Nikki Dunne, Michelle Flood, Eoghan McCarthy, Frank Moriarty   +10 more
wiley   +1 more source

Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

eLife, 2014
Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem ...
Aiguo Tian, Jin Jiang
doaj   +1 more source