Results 141 to 150 of about 5,141,384 (392)
NRASG12V-Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.
Blood, 2018 Abstract In acute myeloid leukemia (AML) standard therapies often induce complete remission, but patients frequently relapse and die of the disease. Leukemia stem cells (LSCs) have self-renewal potential and ability to recapitulate the disease. Our goal is to define the molecular mechanisms that allow AML to relapse.
Marie Lue Antony +10 more
openaire +1 more source
PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal [PDF]
, 2014 Hematopoietic stem cell (HSC) self-renewal is tightly controlled by cytokines and other signals in the microenvironment. While stem cell factor (SCF) is an early acting cytokine that activates the receptor tyrosine kinase KIT and promotes HSC maintenance,
Bai, Yunpeng +10 more
core +1 more source
Financial Distress and Its Determinants in Rheumatoid Arthritis
Arthritis Care &Research, EarlyView.Objective To quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent prolonged use of expensive disease‐modifying therapies. Methods We identified adults enrolled in the FORWARD databank with either RA or noninflammatory musculoskeletal disease (NIMSKD) completing the ...
Amber Brown Keebler +5 more
wiley +1 more source
Fostering the Self-Renewal of Teachers: An Underutilized Approach to Innovating Interdisciplinary Education [PDF]
Journal of Systemics, Cybernetics and Informatics, 2013 Our goal is to call teachers’ attention to the need for selfrenewal, challenging them to consider it a necessary approach to innovating interdisciplinary education.
David J. Waters, Emily C. Chiang
doaj
Figure S5 from MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells
, 2023 Kazuya Fukasawa +14 more
openalex +1 more source
Oncogene, 2018 Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal.
Zhenzhen Chen +8 more
semanticscholar +1 more source
Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca +12 more
core +3 more sources
Arthritis Care &Research, EarlyView.Objective We aimed to test the efficacy of personalized treatment of older veterans with chronic low back pain (CLBP) delivered by Aging Back Clinics (ABCs) as compared with usual care (UC). Methods Two hundred ninety‐nine veterans aged 65 to 89 with CLBP from three Veterans Affairs (VA) medical centers underwent baseline testing, randomization to ABC ...
Debra K. Weiner +9 more
wiley +1 more source
Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex [PDF]
, 2010 Tissue homeostasis depends on the ability of stem cells to properly regulate self-renewal versus differentiation. Drosophila neural stem cells (neuroblasts) are a model system to study self-renewal and differentiation.
Omer Bayraktar +3 more
core +1 more source