Results 11 to 20 of about 5,141,384 (392)
Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
International Journal of Molecular Sciences, 2023 Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a ...
Fahimeh Varzideh +4 more
semanticscholar +1 more source
Nature Communications, 2023 Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in liver tumorigenesis.
Zhenzhen Chen +8 more
semanticscholar +1 more source
An Opposite Effect of the CDK Inhibitor, p18INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells [PDF]
, 2012 Self-renewal is a feature common to both adult and embryonic stem (ES) cells, as well as tumor stem cells (TSCs). The cyclin-dependent kinase inhibitor, p18INK4c, is a known tumor suppressor that can inhibit self-renewal of tumor cells or adult stem ...
Cindy Tian +8 more
core +16 more sources
Cell & Bioscience, 2022 Background Induced hepatic stem cells (iHepSCs) with the capacities of self-renewal and bidifferentiation into hepatocytes and cholangiocytes were generated from mouse embryonic fibroblasts (MEFs) by lineage reprogramming in our previous research ...
Chen Wang +7 more
doaj +1 more source
Regulation of Embryonic Stem Cell Self-Renewal
Life, 2022 Embryonic stem cells (ESCs) are a type of cells capable of self-renewal and multi-directional differentiation. The self-renewal of ESCs is regulated by factors including signaling pathway proteins, transcription factors, epigenetic regulators, cytokines,
Guofang Chen +4 more
doaj +1 more source
Targeting PKCθ promotes satellite cell self-renewal [PDF]
, 2020 Skeletal muscle regeneration following injury depends on the ability of satellite cells (SCs) to proliferate, self-renew, and eventually differentiate. The factors that regulate the process of self-renewal are poorly understood. In this study we examined
Benedetti, Anna +4 more
core +1 more source
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Nature Communications, 2021 Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 ...
Simon Renders +31 more
doaj +1 more source
WDR36 Safeguards Self-Renewal and Pluripotency of Human Extended Pluripotent Stem Cells
Frontiers in Genetics, 2022 Extended pluripotent stem cells (EPS cells) have unlimited self-renewal ability and the potential to differentiate into mesodermal, ectodermal, and endodermal cells.
Shiyu An +7 more
doaj +1 more source
Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects
Frontiers in Cell and Developmental Biology, 2022 Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and differentiation. These properties of HSCs are maintained through hematopoiesis.
Zoya Mann +4 more
doaj +1 more source
Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System. [PDF]
, 2017 Monitoring pluripotent stem cell behaviors (self-renewal and differentiation to specific lineages/phenotypes) is critical for a fundamental understanding of stem cell biology and their translational applications.
Horner, Christopher B +7 more
core +7 more sources