Results 21 to 30 of about 5,141,384 (392)
Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells. [PDF]
PLoS ONE, 2011 Rapid cellular growth and multiplication, limited replicative senescence, calibrated sensitivity to apoptosis, and a capacity to differentiate into almost any cell type are major properties that underline the self-renewal capabilities of human ...
Hock Chuan Yeo +5 more
doaj +1 more source
Nature Immunology, 2020 The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined.
S. Vardhana +12 more
semanticscholar +1 more source
Spermatogonial Stem Cell Self - renewal and Differentiation
Reproductive and Developmental Medicine, 2017 Mammalian spermatogenesis is a complicated and precisely controlled process that requires spermatogonial stem cells (SSCs). SSCs maintain the stem cell pool, balance self-renewal–commitment with differentiation, and produce millions of sperm daily.
Li-Huan Cao, Qiao-Li Zhang, Xin-Hua Lin
doaj +1 more source
macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma
Nature Communications, 2023 Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent an important
Ana Nikolic +29 more
doaj +1 more source
Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
Cell Stem Cell, 2020 N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia
Chao Shen +23 more
semanticscholar +1 more source
WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]
, 2009 Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille +82 more
core +1 more source
Melanoma Stem Cell Sphere Formation Assay
Bio-Protocol, 2017 Self-renewal is the ability of cells to replicate themselves at every cell cycle. Throughout self-renewal in normal tissue homeostasis, stem cell number is maintained constant throughout life.
Alessandra Tuccitto +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 A central issue in regenerative medicine is understanding the mechanisms that regulate the self-renewal of endogenous stem cells in response to injury and disease.
Jaime Imitola +13 more
doaj +1 more source
Mass concentration in a nonlocal model of clonal selection [PDF]
, 2016 Self-renewal is a constitutive property of stem cells. Testing the cancer stem cell hypothesis requires investigation of the impact of self-renewal on cancer expansion. To understand better this impact, we propose a mathematical model describing dynamics
Busse, Jan-Erik +2 more
core +1 more source