Results 31 to 40 of about 5,141,384 (392)

α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal

Stem Cell Reports, 2015
Substrate composition significantly impacts human pluripotent stem cell (hPSC) self-renewal and differentiation, but relatively little is known about the role of endogenously produced extracellular matrix (ECM) components in regulating hPSC fates.
Alex Laperle, Cheston Hsiao, Michael Lampe, Jaime Mortier, Krishanu Saha, Sean P. Palecek, Kristyn S. Masters   +6 more
doaj   +1 more source

Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal. [PDF]

PLoS ONE, 2017
Activation of signal transducer and activator of transcription 3 (STAT3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal.
Ling Tang, Manman Wang, Dahai Liu, Mengting Gong, Qi-Long Ying, Shoudong Ye   +5 more
doaj   +1 more source

Signaling pathways governing the maintenance of breast cancer stem cells and their therapeutic implications

Frontiers in Cell and Developmental Biology, 2023
Breast cancer stem cells (BCSCs) represent a distinct subpopulation of cells with the ability to self-renewal and differentiate into phenotypically diverse tumor cells.
Alejandro Ordaz-Ramos, Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez, Olivia Tellez-Jimenez, Karla Vazquez-Santillan   +4 more
doaj   +1 more source

Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal

Stem Cell Reports, 2015
Spermatogonial stem cells (SSCs) are required for spermatogenesis. Earlier studies showed that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal by binding to the GFRA1/RET receptor.
Seiji Takashima, Mito Kanatsu-Shinohara, Takashi Tanaka, Hiroko Morimoto, Kimiko Inoue, Narumi Ogonuki, Mayumi Jijiwa, Masahide Takahashi, Atsuo Ogura, Takashi Shinohara   +9 more
doaj   +1 more source

Transcriptional regulation of neural stem cell expansion in the adult hippocampus

eLife, 2022
Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors (TFs) in RGLs integrate physiological signals to dictate self-renewal division mode.
Nannan Guo, Kelsey D McDermott, Yu-Tzu Shih, Haley Zanga, Debolina Ghosh, Charlotte Herber, William R Meara, James Coleman, Alexia Zagouras, Lai Ping Wong, Ruslan Sadreyev, J Tiago Gonçalves, Amar Sahay   +12 more
doaj   +1 more source

Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling

Frontiers in Molecular Neuroscience, 2017
Revealing the molecular mechanisms underlying neural stem cell self-renewal is a major goal toward understanding adult brain homeostasis. The self-renewing potential of neural stem and progenitor cells (NSPCs) must be tightly regulated to maintain brain ...
Tal Burstyn-Cohen, Katya Zelentsova-Levytskyi, Ziv Talmi, Ghada Abboud-Jarrous, Tal Capucha, Tamar Sapir   +5 more
doaj   +1 more source

m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

Cell Reports, 2017
Summary RNA modifications play critical roles in important biological processes. However, the functions of N6-methyladenosine (m6A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. Here, we show that m6A mRNA modification
Qi Cui, Hailing Shi, Peng Ye, Li Li, Qiuhao Qu, Guoqiang Sun, Guihua Sun, Zhike Lu, Yue Huang, Cai-Guang Yang, A. Riggs, Chuan He, Yanhong Shi   +12 more
semanticscholar   +1 more source

TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Reproductive success in placental mammals relies on proper development of the trophoblast lineage. In particular, a proper balance in self-renewal vs. differentiation of trophoblast progenitors is critical for establishment of pregnancy.
Biswarup Saha, A. Ganguly, P. Home, B. Bhattacharya, S. Ray, Ananya Ghosh, M. Rumi, Courtney Marsh, Valerie French, S. Gunewardena, S. Paul   +10 more
semanticscholar   +1 more source

Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway

Cellular Physiology and Biochemistry, 2015
Background/Aims: Puerarin shows a wide range of biological activities, including affecting the cardiac differentiation from murine embryonic stem (mES) cells.
Mengmeng Yin, Yin Yuan, Yurong Cui, Xian Hong, Hongyan Luo, Xinwu Hu, Ming Tang, Jurgen Hescheler, Jiaoya Xi   +8 more
doaj   +1 more source

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal [PDF]

, 2013
Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self-renewal are unclear.
Alessia Gagliardi, Ambrosetti DC, Ambrosetti DC, Anastasia Felker, Anastasia I Kousa, Avilion AA, Bailey TL, Bogan AA, Brookes E, Chambers I, Chambers I, Chen X, Chen X, Costa Y, DeLano WL, Dignam JD, Douglas Colby, Engelen E, Favaro R, Festuccia N, Fidalgo M, Florian Halbritter, Gao Z, Genzor CG, Halbritter F, Han JD, Harley VR, Hatano SY, Ho SN, Hooper M, Hutchins AP, Ian Chambers, Jang H, Jason T Weiss, Jauch R, Jepsen K, Jeroen Demmers, Karel Bezstarosti, Kim J, Laemmli UK, Lam CS, Liang J, Ma T, Marson A, Maruyama M, Masui S, McDonel P, Mitsui K, Moretto-Zita M, Mullin NP, Navarro P, Navarro P, Nicholas P Mullin, Noble SM, Pardo M, Parisi S, Perkins DN, Qin J, Raymond A Poot, Rebecca Favaro, Remenyi A, Reynolds N, Rogers MS, Rugg-Gunn PJ, Shi W, Silvia K Nicolis, Simon R Tomlinson, Singh AM, Smith AG, Surface LE, Ura H, van den Berg DL, Wang J, Wang Z, Whyte WA, Wu Q, Yates A, Yuan H, Zappone MV, Zi Ying Tan   +79 more
core   +1 more source