Results 41 to 50 of about 5,141,384 (392)
LHPP-Mediated Histidine Dephosphorylation Suppresses the Self-Renewal of Mouse Embryonic Stem Cells
Frontiers in Cell and Developmental Biology, 2021 Self-renewal of embryonic stem cells (ESCs) is orchestrated by a vast number of genes at the transcriptional and translational levels. However, the molecular mechanisms of post-translational regulatory factors in ESC self-renewal remain unclear ...
Rong Mu Xia +3 more
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Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
core +1 more source
Cell Reports, 2017 LIF promotes self-renewal of mouse embryonic stem cells (mESCs), and in its absence, the cells differentiate. LIF binds to the LIF receptor (LIFR) and activates the JAK-STAT3 pathway, but it remains unknown how the receptor complex triggers ...
Xiong-jun Wang +15 more
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Distribution of interstitial stem cells in Hydra [PDF]
, 1979 The distribution of interstitial stem cells along the Hydra body column was determined using a simplified cloning assay. The assay measures stem cells as clone-forming units (CFU) in aggregates of nitrogen mustard inactivated Hydra tissue.
Bode +16 more
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Stem Cell Research & Therapy, 2023 Background The therapeutic application of multipotent mesenchymal stem cells (MSCs) encounters significant challenges, primarily stemming from their inadequate growth and limited self-renewal capabilities.
Matteo Mazzella +7 more
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Asian Journal of Andrology, 2015 Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells.
Xing-Xing Mei, Jian Wang, Ji Wu
doaj +1 more source
Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]
, 2012 Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina +5 more
core +2 more sources
Self-Renewing Macrophages [PDF]
Science Signaling, 2009 The absence of two transcription factors allows long-term propagation of a differentiated immune cell population that is nontumorigenic.
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FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]
, 2015 FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J +12 more
core +2 more sources
Stem Cell Reports, 2016 Spermatogenesis originates from self-renewal of spermatogonial stem cells (SSCs). Previous studies have reported conflicting roles of gonadotropic pituitary hormones in SSC self-renewal.
Takashi Tanaka +4 more
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