Results 51 to 60 of about 5,141,384 (392)
eLife, 2020 How adult stem cells maintain self-renewing tissues is commonly assessed by analysing clonal data from in vivo cell lineage-tracing assays. To identify strategies of stem cell self-renewal requires that different models of stem cell fate choice predict ...
Cristina Parigini, Philip Greulich
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Essential role of proteasomes in maintaining self-renewal in neural progenitor cells [PDF]
, 2016 Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent phenotypes induced by intensive ...
A Kitamura +46 more
core +1 more source
A resource for discovering specific and universal biomarkers for distributed stem cells. [PDF]
PLoS ONE, 2011 Specific and universal biomarkers for distributed stem cells (DSCs) have been elusive. A major barrier to discovery of such ideal DSC biomarkers is difficulty in obtaining DSCs in sufficient quantity and purity.
Minsoo Noh +3 more
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Wnt5a Signaling in Normal and Cancer Stem Cells. [PDF]
, 2017 Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner.
Kipps, Thomas J +2 more
core +2 more sources
Self-Renewal Made Simple [PDF]
Cell Stem Cell, 2008 Embryonic stem cells (ESCs) are prone to differentiation in culture, suggesting that maintenance of the pluripotent state must be actively induced. In a recent issue of Nature, Ying et al. (2008) use soluble small molecules to inhibit pro-differentiation signals and reveal ESC self-renewal as a default cell fate.
openaire +2 more sources
Molecular Cancer, 2019 N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year.
Chaohui Gu +8 more
semanticscholar +1 more source
Cell Stem Cell, 2018 Cellular diversity that shapes tissue architecture and function is governed by multiple niche signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been challenging. Based on niche ligands present in the natural stem cell
Masayuki Fujii +7 more
semanticscholar +1 more source
Autophagy and Stem Cells: Self-Eating for Self-Renewal
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a fundamental cell survival mechanism that allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy.
N. Chang
semanticscholar +1 more source
NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1 [PDF]
, 2010 The balance between self-renewal and differentiation of neural progenitor cells is an absolute requirement for the correct formation of the nervous system.
Bailey, Timothy L. +13 more
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ZFX controls the self-renewal of human embryonic stem cells. [PDF]
PLoS ONE, 2012 Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer great promise in regenerative medicine and disease modeling due to their unlimited self-renewal and broad differentiation capacity.
Sivan Harel +9 more
doaj +1 more source