Results 91 to 100 of about 13,921,856 (304)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Thermodynamic Theory of Macrosystems: Entropy Production as a Metric

Entropy
The article considers the description of a macrosystem in terms that do not depend on the nature of the macrosystem. The results obtained can be used to describe macrosystem models of thermodynamic processes, and to create interdisciplinary models that ...
Sergey Amelkin
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Integer-valued self-similar processes

, 1985
Let IN0 denote the set of nonnegative integers. We consider IN0-valued analogues of self-similar processes by defining Unvalued fractions of IN0-valued processes.
Harn, van, K., Steutel, F.W.
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The visible part of plane self-similar sets [PDF]

, 2012
JMF was supported by an EPSRC grant whilst undertaking this work.Given a compact subset F of R2, the visible part VθF of F from direction θ is the set of x in F such that the half-line from x in direction θ intersects F only at x. It is suggested that if
Fraser, Jonathan Macdonald, Fraser, Jonathan M., Falconer, Kenneth John, Falconer, Kenneth J.   +3 more
core   +1 more source

Lower Tails of Self-Similar Stable Processes [PDF]

Bernoulli, 1998
This paper is concerned with the validity or otherwise of inequalities such as for instance \[ C^{-1}\varepsilon^{-d} \leq-\log P\Bigl( \sup_{0\leq t\leq 1}\bigl|X(t)\bigr |\leq \varepsilon \Bigr)\leq C \varepsilon^{-d}\quad (00\), is this \(d\) determined by the index of stability \(\alpha\) and the parameter of self-similarity \(H\) of the process ...
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Social stress task with parental support or self-instruction decreases negative cognitions in children with social anxiety disorder

Scientific Reports
Social anxiety disorder (SAD) is highly prevalent in childhood, yet research on cognitive processes in children with SAD is limited. This study examined anticipatory rumination (AR), self-focused attention (SFA), and post-event processing (PEP) in ...
Nadine Vietmeier, Brunna Tuschen-Caffier, Julia Asbrand   +2 more
doaj   +1 more source