Results 71 to 80 of about 855,984 (269)
Electrodynamics of geoenvironment and methods of geoelectrics
Геофизический журнал, 2010 A brief review of a set of aspects of interaction of electromagnetic waves with geological medium, models of geo-medium and mechanic-electro-magnetic-transformations in it has been done.
V. N. Shuman
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Frontiers in Psychology, 2014 The learning advantages of self-controlled feedback schedules compared to yoked schedules have been attributed to motivational influences and/or information-processing activities with many researchers adopting the motivational perspective in recent years.
Michael J Carter +2 more
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A representation for self-similar processes
Stochastic Processes and their Applications, 1978 AbstractA self-similar process Z(t) has stationary increments and is invariant in law under the transformation Z(i)→c-HZ(ct), c⩾0.
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Self‐similar processes in collective risk theory [PDF]
International Journal of Stochastic Analysis, 1998 Collective risk theory is concerned with random fluctuations of the total assets and the risk reserve of an insurance company. In this paper we consider self‐similar, continuous processes with stationary increments for the renewal model in risk theory. We construct a risk model which shows a mechanism of long range dependence of claims.
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Thermodynamic Theory of Macrosystems: Entropy Production as a Metric
EntropyThe article considers the description of a macrosystem in terms that do not depend on the nature of the macrosystem. The results obtained can be used to describe macrosystem models of thermodynamic processes, and to create interdisciplinary models that ...
Sergey Amelkin
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