Results 131 to 140 of about 283,468 (264)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Adhesive creases: bifurcation, morphology and their (apparent) self-similarity.
Soft Matter, 2023 Essink MH +4 more
europepmc +1 more source
Self-similar energies on p.c.f. self-similar fractals
, 2016 On a large class of pcf (finitely ramified) self-similar fractals with possibly little symmetry we consider the question of existence and uniqueness of a Laplace operator. By considering positive refinement weights (local scaling factors) which are not necessarily equal we show that for each such fractal, under a certain condition, there are ...
Hambly, B, Metz, V, Teplyaev, A
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RETRACTION: LncRNA AATBC Regulates Pinin to Promote Metastasis in Nasopharyngeal Carcinoma
Molecular Oncology, EarlyView.RETRACTION: T. Tang, L. Yang, Y. Cao, M. Wang, S. Zhang, Z. Gong, F. Xiong, Y. He, Y. Zhou, Q. Liao, B. Xiang, M. Zhou, C. Guo, X. Li, Y. Li, W. Xiong, G. Li, and Z. Zeng, “LncRNA AATBC Regulates Pinin to Promote Metastasis in Nasopharyngeal Carcinoma,” Molecular Oncology 14, no. 9 (2020): 2251‐2270, https://doi.org/10.1002/1878‐0261.12703.
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
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Depressurization-Induced Nucleation in the "Polylactide-Carbon Dioxide" System: Self-Similarity of the Bubble Embryos Expansion. [PDF]
Polymers (Basel), 2021 Zimnyakov D, Alonova M, Ushakova E.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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[Pathological voice detection based on gammatone short time spectral self-similarity]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2022 Zhao D, Zhou C, Zhu X, Zhang X, Tao Z.
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New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
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