Results 91 to 100 of about 6,174,327 (312)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

SoK: Self-Sovereign Digital Identities

CoRR
Self-Sovereign Digital Identity (SSDI) enables individuals to control their own identity assertions and data, rather than relying on centralized or federated systems prone to large-scale data breaches. By eliminating centralized databases maintained by service providers and identity brokers, SSDIs offer enhanced security and privacy.
Sushanth Ambati, Kainat Adeel, Jack Myers, Nikolay Ivanov   +3 more
openaire   +3 more sources

DNS-IdM: A Blockchain Identity Management System to Secure Personal Data Sharing in a Network

Applied Sciences, 2019
Identity management (IdM) is a method used to determine user identities. The centralized aspect of IdM introduces a serious concern with the growing value of personal information, as well as with the General Data Protection Regulation (GDPR). The problem
Jamila Alsayed Kassem, Sarwar Sayeed, Hector Marco-Gisbert, Zeeshan Pervez, Keshav Dahal   +4 more
doaj   +1 more source

SSIBAC: Self-Sovereign Identity Based Access Control [PDF]

, 2020
Data breaches combined with ineffective data management practises pose serious issues to consumers and enterprises, such as identity theft and online exposure.
Belchior, Rafael, Pernul, Günther, Guerreiro, Sérgio, Putz, Benedikt, Correia, Miguel, Vasconcelos, André   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A shared responsibility model to support cross border and cross organizational federation on top of decentralized and self-sovereign identity

, 2023
97108This paper discusses the challenges of transitioning from legacy federated identity systems to emerging decentralized identity technologies based on self-sovereign identities (SSI) and verifiable credentials, which are being used in initiatives such
Alangot, Bithin, Krontiris, Ioannis, Henderson, Isaac, Dimitrakos, Theo, Vargas, Juan, Bithin, Alangot, Winterstetter, Matthias, Kubach, Michael, Johnson Jeyakumar, Isaac Henderson   +8 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Towards a Modelling Framework for Self-Sovereign Identity Systems [PDF]

, 2020
Self-sovereign Identity promises to give users control of their own data, and has the potential to foster advancements in terms of personal data privacy. Self-sovereign concepts can also be applied to other entities, such as datasets and devices. Systems
Radha, Swapna, Freytsis, Maria, Taylor, Ian, Barclay, Iain, Bucher, Sherri, Preece, Alun   +5 more
core   +1 more source