Results 111 to 120 of about 6,174,327 (312)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Selective Disclosure Approaches in Self-Sovereign Identity: An Experimental Comparison

IEEE Access
The Self-Sovereign Identity (SSI) paradigm empowers individuals to manage their own credentials by storing them in digital wallets under their full control.
Andrea De Salve, Andrea Lisi, Maurizio Cascino, Paolo Mori, Laura Ricci   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The ECTLC-Horcrux Protocol for Decentralized Biometric-Based Self-Sovereign Identity with Time-Lapse Encryption

International Journal of Advanced Computer Science and Applications
—In the era of rapid development of digital communication, there is a growing need for technologies that guarantee secure user identification, document authentication and protection of personal data, including biometrics.
N. Kaziyeva, R. Ospanov, N. Issayev, K. Maulenov, Shakhmaran Seilov   +4 more
semanticscholar   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Keycloak-SSI: Post-Authentication Attribute Verification in Federated Identity Management Using Self-Sovereign Identity

IEEE International Symposium on Network Computing and Applications
Federated Identity Management (FIM) allows different domains or organizations to use the same identification data. With FIM, an Identity Provider (IdP) can provide attributes or credentials to a Service Provider (SP) based on a trust relationship ...
Mauladi, Ramin Yahyapour
semanticscholar   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

AASSI: A Self-Sovereign Identity Protocol With Anonymity and Accountability

IEEE Access
The concern and opposition to centralized management of user identities by third-party authorities have led to the emergence of Self-Sovereign Identity (SSI).
Le Gao, Jiaxin Yu, Junzhe Zhang, Yin Tang, Quansi Wen   +4 more
doaj   +1 more source