Results 241 to 250 of about 3,241,760 (311)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control. [PDF]

Pharmacol Rev
Banks ML, Negus SS, Varshneya NB, Reissig CJ, Chiapperino D, Strickland JC, Reed DD, Hursh SR, Kearns DN.   +8 more
europepmc   +1 more source

Differential Modulation of Glutamate Transporter-1 by Cocaine and Oxycodone and the Efficacy of MC-100093 to Reduce Reinstatement of Self-Administration. [PDF]

Brain Behav
Hart DW, Alonso-Caraballo Y, Hornback B, Robert A, Brickner MA, Esguerra M, Childers WE, Abou-Gharbia M, Thomas MJ.   +8 more
europepmc   +1 more source

Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior. [PDF]

Cell Rep
Testen A, VanRyzin JW, Bellinger TJ, Kim R, Wang H, Gastinger MJ, Witt EA, Franklin JP, Vecchiarelli HA, Picard K, Scofield MD, Tremblay MÈ, Reissner KJ.   +12 more
europepmc   +1 more source

Association of Eye Drop-Treated Diseases and Conditions That Can Impair Eye Drop Self-Administration. [PDF]

Ophthalmol Glaucoma
Wang T, An HS, Stoutin J, Valentine AD, Depperschmidt LK, Callewaert M, Goldstein M, Stein JD, SOURCE consortium.   +8 more
europepmc   +1 more source

Barriers, facilitators and implementation strategies to implement 'patient's own medication' and 'self-administration of medication' in hospitals. [PDF]

Int J Qual Health Care
Smale EM, van den Berg J, Korporaal-Heijman J, Bekker CL, van den Bemt BJF.   +4 more
europepmc   +1 more source

Alternating self-administration sessions of cocaine and heroin impact drug-related motivation and vocalisations in rats. [PDF]

Psychopharmacology (Berl)
Adamatzky K, Collins AC, Badiani A, Singer BF.   +3 more
europepmc   +1 more source

Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity

Hesen R, Mottarlini F, Caffino L, Fennema S, Parolaro S, Guerrin CGJ, Quednow BB, Fumagalli F, Verheij MM, Homberg JR.   +9 more
europepmc   +1 more source

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Intracranial self-administration methodologies

Neuroscience & Biobehavioral Reviews, 1987
Intracranial drug self-administration (ICSA) offers a relatively new approach for investigating the neurobiological mechanisms involved in brain reinforcement processes. Discrete brain regions responsible for the initiation of neuronal activity associated with the response-contingent delivery of a drug reinforcer can be identified using these ...
N E, Goeders, J E, Smith
openaire   +2 more sources