Results 81 to 90 of about 7,194,541 (265)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The role of GABAB receptors in morphine self-administration

International Journal of Preventive Medicine, 2013
Background: There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self ...
Effat Ramshini, Hojjatallah Alaei, Parham Reisi, Samaneh Alaei, Somaye Shahidani   +4 more
doaj  

Support for a reciprocal effects model of self-concept and academic achievement through a contrast of multidimensional and unidimensional approaches

, 2006
There is a longstanding debate in the self-concept literature surrounding the causal ordering of self-concept and academic achievement. Some researchers have argued that self-esteem has no positive impact upon performance (Baumeister, Campbell, Krueger &
Marsh, Herbert W., O'Mara, Alison J.
core  

The role of 5-HT1A and 5-HT1B receptors in MDMA self-administration

, 2016
Rationale: 3,4-methylenedioxymethamphetamine (MDMA) is a less efficacious reinforcer than other drugs of abuse. However, following repeated self-administration, responding increases for some animals and efficacy becomes comparable to other drugs of abuse.
Aronsen, Dane (11707085), Aronsen, Dane
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Investigating self-concept and health-related quality of life

, 2006
Health-related quality of life has been an important topic of research in diverse fields such as medicine, nursing, community service provision and psychology.
Dowson, Martin, Martin, Andrew J., Martinez, Carissa J.   +2 more
core  

Locomotor activity: A distinctive index in morphine self-administration in rats. [PDF]

, 2017
Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively ...
Qingyao Kong, Kong, Qingyao, Jian-Jun Zhang, Zhang, Jian-Jun   +3 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Systematic literature review of asthma biologic self-administration enhanced by a patient perspective

Journal of Allergy and Clinical Immunology: Global
Background: Several biologics for the treatment of severe asthma are available as self-administration devices. Objective: We performed a systematic literature review to understand the use, benefits, and challenges of these self-administration devices ...
Simona Boccaletti, MSc, Rafael Alfonso-Cristancho, PhD, Waseem Ahmed, MBA, Lehanne Sergison, Adaeze Eze, MSc, Prashant Auti, MS (Pharm), Cathelijne Alleman, MSc, Lohit Badgujar, PhD, Nicholas Halfpenny, MSc, Dorothea Heldt, MSc   +9 more
doaj   +1 more source